IP Library › Granted Patent US 8,895,579
Granted Patent B2
US 8,895,579 · App. 13/052,742 · Granted Nov 25, 2014

Heterotricyclic AMPA receptor antagonists for treatment of epilepsy, pain, and other neurological disorders and diseases

Inventors: Geoffrey T. Swanson (Oak Park, IL); Martin B. Gill (Indianapolis, IN); Ryuichi Sakai (Hakodate, JP); Masato Oikawa (Kanagawa, JP)
Assignee: Northwestern University
A61K31/437A61K31/407
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Quick Facts
Patent No.
US 8,895,579
App. No.
13/052,742
Granted
Nov 25, 2014
Kind
B2
Abstract

Disclosed are heterotricyclic compounds, pharmaceutical compositions, methods of treatment, and methods for selectively antagonizing a glutamate receptor. The pharmaceutical compositions may include and the methods may utilize heterotricyclic compounds that are glutamate analogues which have specificity for AMPA receptors. The pharmaceutical compositions may be utilized to treat or prevent neurological diseases or disorders.

Claims (7)

1. A pharmaceutical composition comprising:

(a) a compound having a formula:

or a salt or solvate thereof; and

(b) one or more pharmaceutically acceptable carriers, diluents, or excipients.

2. The composition of claim 1 , wherein the composition is suitable for administration to a human.

3. The composition of claim 1 , wherein the composition is suitable for oral administration.

4. The composition of claim 1 , wherein the composition is suitable for transdermal administration.

Assignments (3)
CONFIRMATORY LICENSE Recorded Jan 16, 2015
From: NORTHWESTERN UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 034780/0106 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 17, 2011
From: SWANSON, GEOFFREY T.; GILL, MARTIN B.
To: NORTHWESTERN UNIVERSITY
Reel/Frame 026763/0405 →
CONFIRMATORY LICENSE Recorded Jun 15, 2011
From: NORTHWESTERN UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 026444/0673 →
Continuity (2)
Provisional Application 61315636 · Mar 19, 2010
Related Publication 20120071423A1 · Mar 22, 2012