Methyl 3-(benzyloxy)-1-(2,2-dihydroxyethyl)-4-oxo-1,4-dihydropyridine-2-carboxylate and processes for the preparation thereof
The present invention features compounds that are prodrugs of HIV integrase inhibitors and therefore are useful in the delivery of compounds for the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC. For example, the present invention includes methyl 3-(benzyloxy)-1-(2,2-dihydroxyethyl)-4-oxo-1,4-dihydropyridine-2 -carboxylate of the formula P-8: and processes for the preparation thereof.
1. A compound of formula P-8
2. A process for the preparation of a compound of formula P-8
comprising the steps of:
a) treating a compound of formula P-5
with 3-amino-propane-1,2-diol to form a compound of formula P-6
b) methylating a compound of formula P-6 to form a compound of formula P-7
c) treating a compound of formula P-7 with NaIO 4 to form a compound of formula P-8.
3. A process for the preparation of a compound of formula P-8
comprising the steps of:
a) methylating a compound of formula P-6
to form a compound of formula P-7
b) treating a compound of formula P-7 with NaIa 4 to form a compound of formula P-8.