IP Library › Granted Patent US 9,101,537
Granted Patent B2
US 9,101,537 · App. 13/055,691 · Granted Aug 11, 2015

Compositions and methods for the prevention and treatment of cardiovascular diseases

Inventors: Henk Van Wyk (Denver, CO); Mariette Van Wyk (Denver, CO); Trace Krebs (Sarasota, FL); Peter Lange (Denver, CO); Brian Denomme (Northville, MI); Michael A. Volk (Broomfield, CO)
Assignee: REVEN PHARMACEUTICALS, INC.
A61K9/0019A61K31/375A61K31/4415A61K31/455A61K31/51A61K31/519A61K31/525A61K33/00A61K33/06A61K33/14
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Quick Facts
Patent No.
US 9,101,537
App. No.
13/055,691
Granted
Aug 11, 2015
Kind
B2
Abstract

Compositions comprising electro-activated aqueous solutions and methods for the prevention and treatment of dysfunctional cardiovascular conditions are provided.

Claims (30)

1. A therapeutic composition for parenteral injection comprising an electro-activated solution, wherein the electro-activated solution has an oxidation-reduction potential (ORP) in the range between −50 mV and −500 mV for a period of at least 12 months, a conductivity in the range between 11 and 15 mS/cm and a pH in the range between 6.5 and 7.6; and wherein the electro-activated solution consists essentially of:

Nicotinic Acid

190-220

mg;

Thiamin

9.5-11.0

mg;

Riboflavin

1.9-2.2

mg;

Folic Acid

285.0-330.0

mg;

Cyanocobalamin

23.7-27.5

μg;

Pyridoxin

23.7-27.5

μg;

Electro-Activated Water

to 10

ml;

Magnesium sulfate hexahydrate

50-1000

mg;

and

Ascorbic Acid

228-264.0

mg.

2. The therapeutic composition of claim 1 , wherein the electro-activated solution further comprises 0.5-1.0 g/l of sodium bicarbonate and 8.0-10.0 g/l of sodium chloride.

Assignments (3)
CHANGE OF ASSIGNEE'S ADDRESS Recorded Nov 21, 2014
From: REVEN PHARMACEUTICALS, INC.
To: REVEN PHARMACEUTICALS, INC.
Reel/Frame 034311/0631 →
CHANGE OF NAME Recorded Nov 21, 2014
From: NOVENTIS, INC.
To: REVEN PHARMACEUTICALS, INC.
Reel/Frame 034316/0560 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 14, 2011
From: VAN WYK, HENK; VAN WYK, MARIETTE; KREBS, TRACY L.; LANGE, PETER B.; DENOMME, BRIAN; VOLK, MICHAEL A.
To: NOVENTIS, INC.
Reel/Frame 026127/0670 →
Continuity (2)
Provisional Application 61129883 · Jul 25, 2008
Related Publication 20110262563A1 · Oct 27, 2011