Crystalline forms of a pyridine derivative
The invention relates to 4-methylbenzenesulfonate salt of the compound of formula (I) in a crystalline form or a solvate thereof, pharmaceutical formulations containing them, their use in therapy and processes for preparing the same.
1. 4-methylbenzenesulfonate salt of the compound of formula (I)
or a hydrate thereof in a crystalline form.
2. 4-methylbenzenesulfonate salt of the compound of formula (I) in a crystalline form as claimed in claim 1 , wherein the crystalline form is anhydrous.
3. 4-methylbenzenesulfonate salt of the compound of formula (I) in a crystalline form as claimed in claim 1 , wherein the crystalline form is hydrate.
4. 4-methylbenzenesulfonate salt of the compound of formula (I) in a crystalline form as claimed in claim 1 , wherein the crystalline form is anhydrous crystalline Form 1 characterized by substantially the same X-ray powder diffraction (XRPD) pattern as in FIG. 1 .
5. 4-methylbenzenesulfonate salt of the compound of formula (I) in a crystalline form as claimed in claim 1 , wherein the crystalline form is anhydrous crystalline Form 2 characterized by substantially the same X-ray powder diffraction (XRPD) pattern as in FIG. 3 .
6. 4-methylbenzenesulfonate salt of the compound of formula (I) in a crystalline form as claimed in claim 1 , wherein the crystalline form is hydrate 1 characterized by substantially the same X-ray powder diffraction (XRPD) pattern as in FIG. 5 .
7. A pharmaceutical composition comprising 4-methylbenzenesulfonate salt of the compound of formula (I) or a hydrate thereof in a crystalline form according to claim 1 .
8. A pharmaceutical composition according to claim 7 further comprising one or more pharmaceutically acceptable carriers or diluents.
9. A method for the treatment of psychotic disorders, depression, mood disorders, anxiety, sleep disorders and alcohol dependence comprising administering to the mammal, an effective amount of 4-methylbenzenesulfonate salt of the compound of formula (I) or a hydrate thereof in a crystalline form according to claim 1 .