Lipid compounds for suppression of tumorigenesis
View Patent ↗The present invention provides compounds, or pharmaceutically acceptable salts or analogs thereof, which exhibit anti-tumor activity. The present invention also includes methods for inhibiting the growth of cancer cells by contacting an effective amount of a compound of the present invention with the cancer cells in vitro or in vivo.
1. A compound or pharmaceutically acceptable salt thereof, wherein the compound has the formula:
2. The compound or pharmaceutically acceptable salt thereof of claim 1 , wherein said compound is:
3. The compound or pharmaceutically acceptable salt thereof of claim 1 , wherein said compound is:
or the cis isomer thereof.
4. A composition comprising a combination of two or more compounds selected from the group consisting of:
or the cis isomer thereof.
5. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier, adjuvant, diluent, or excipient.
6. The pharmaceutical composition of claim 5 , further comprising an immunomodulating agent, an antioxidant, a free radical scavenging agent, a peptide, a growth factor, an antibiotic, a bacteriostatic agent, an immunosuppressive agent, an anticoagulant, a buffering agent, an anti-inflammatory agent, an anti-pyretic, a time-release binder, an anesthetic, a steroid, or a corticosteroid.
7. The pharmaceutical composition of claim 5 , further comprising a second active pharmaceutical ingredient (API) in addition to said compound or pharmaceutically acceptable salt thereof.
8. The pharmaceutical composition of claim 7 , wherein the second API is an anti-cancer agent.
9. A pharmaceutical composition comprising a composition according to claim 4 and a pharmaceutically acceptable carrier, adjuvant, diluent, or excipient.
10. The pharmaceutical composition of claim 9 , further comprising an immunomodulating agent, an antioxidant, a free radical scavenging agent, a peptide, a growth factor, an antibiotic, a bacteriostatic agent, an immunosuppressive agent, an anticoagulant, a buffering agent, an anti-inflammatory agent, an anti-pyretic, a time-release binder, an anesthetic, a steroid, or a corticosteroid.
11. The pharmaceutical composition of claim 9 , further comprising a second active pharmaceutical ingredient (API) in addition to said compound or pharmaceutically acceptable salt thereof.
12. The pharmaceutical composition of claim 11 , wherein the second API is an anti-cancer agent.