Glycoside compounds and pharmaceutical compositions thereof
The present invention provides glycoside compounds, methods of preparing such compounds, pharmaceutical compositions comprising such compounds, and a method for the treatment of hyperproliferative diseases using the same.
1. A compound of formula I
or a pharmaceutically acceptable ester, conjugate, hydrate, solvate or salt thereof, wherein R 1 is selected from the group consisting of
R 2 and R 3 are each hydrogen, or R 2 and R 3 along with the attached carbons represent a carbon-carbon double bond;
R 4 is selected from the group consisting of
and their epimers and conformers;
and X is O.
2. A pharmaceutical composition comprising a compound claim 1 and at least one pharmaceutically acceptable excipient.
3. The pharmaceutical composition of claim 2 wherein the at least one pharmaceutically acceptable excipient is a cyclodextrin.
4. A method of treating a hyperproliferative disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound of claim 1 .
5. A method of treating cancer in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition of claim 2 .
6. The method of claim 5 wherein the cancer is selected from colorectal, non-small cell, lung, ovarian, breast, colon, CNS, liver, lung, and kidney cancers.