Chamber for housing animals during anaesthetic procedures
The present invention provides a chamber having at least one operator hand access port; the port comprising a port aperture located within the chamber wall; and at least two flexible non-resilient lightweight sealing gas-tight flaps (SFs), disposed the same plane of the port aperture in an overlapping manner, entirely enclosing the port aperture; each of the SFs is defined by a port aperture edge and chamber edges; the chamber edges are anchored to the chamber wall along more than half of the perimeter of the flap, at a distance from the center of the port greater than the radius of the port and beyond its perimeter; the port aperture edge of each flap is stretched across an entire chord of the port aperture; stretched port apertures edges define an interior access zone, disposed the same plane of the port aperture, characterized solely by the port aperture edges.
1. A closed chamber having a positive pressure of gas there inside, the chamber comprising at least one gas-tight operator hand access port configured to enable an operator to access and manipulate subjects located within said chamber without gas escaping from the chamber into the surrounding environment;
wherein said at least one hand access port comprises:
a port aperture located within a chamber wall;
at least two first partially overlapping flexible and elastic lightweight sealing gas-tight flaps (SFs) disposed within the same plane of said port aperture, forming at least one first overlapping area, said at least two first SFs entirely enclosing said port aperture, and
at least two second partially overlapping SFs overlaid on said first SFs in contact therewith, forming at least one second overlapping area, said at least one first and at least one second overlapping areas are orthogonal to each other;
wherein each of said SFs is defined by a port aperture edge and chamber edges, said chamber edges are anchored to said chamber wall and said port aperture edge is a straight line stretched across an entire chord of said port aperture,
wherein said at least one first and said at least one second overlapping areas are formed between respective aperture edges of said at least two first and at least two second partially overlapping SFs such that said port aperture edges define at least two interior access zones, and wherein access into said chamber through said at least two interior access zones is provided by at least one change of direction of said operator's hand.
2. The chamber of claim 1 , wherein each of said SFs is a sheet-like member defined in a shape selected from a group consisting of truncated circle; polygon; and any combination thereof.
3. The chamber of claim 1 , comprising SFs in a number ranging from a group consisting of from 2 to 6; from 4 to 10; from 6 to 18; and from 10 to 60.
4. The chamber of claim 1 , comprising a plurality of N operator hand access ports; N is integer greater than 1.
5. The chamber of claim 1 , wherein said chamber comprising at least one inlet and/or outlet to provide a fluid to and/or from said chamber, such that the pressure and/or volume of said fluid within said chamber is different from outside said chamber; further wherein SFs provide fluid-tight sealing across said port aperture during operation of said chamber and manipulations therein.
6. The chamber of claim 1 , adapted by means of size and shape for housing animals.
7. The chamber of claim 1 , adapted by means of size and shape for treating anaesthetized animals, said chamber is characterized by a mechanism to provide a positive anaesthetizing gas pressure within said at least a portion of said chamber's volume.
8. The chamber of claim 1 , wherein said at least one access port is located on a location selected from a group consisting of the side of said chamber; the bottom of said chamber; the roof of said chamber and a combination thereof.
9. The chamber of claim 1 , wherein said chamber is provided with a hermetically sealed communication means to a small mammal imaging device, such that said small mammal may be inserted and withdrawn from said imaging device without escape of gas from the interior of said chamber.
10. The chamber of claim 1 , wherein said chamber is adapted by means of size and shape to at least reversibly accommodate at least one animal, said chamber comprising at least one mechanism selected from a group consisting of a drop system mechanism for administration of a fluid to said animal; an anesthetic machine for administration of anaesthesia to said animal; fluid feeding mechanism for administration of at least one drug to said animal; fluid feeding mechanism for administration of at least one food to said animal; fluid feeding mechanism for administration at least one drink to said animal; optical magnifying means (OMM) for viewing said animals; apertures for immobilizing, medically treating and/or imaging said animal; and any combination thereof.
11. A method for manipulating, medically treating or imaging animal during anaesthetic procedures without exposure to escaping gases, wherein said method comprising:
a) providing a chamber according to claim 1 ;
b) placing said animal in said chamber;
c) anaesthetizing said animal with an anaesthetizing gas; and
d) manipulating said animal via said at least one hand access port such that substantially no gases escape from said chamber.
12. An integrated imaging system for imaging or otherwise treating anesthetized animals, said system comprising (a) a chamber according to claim 1 set in a shape and dimension to at least temporarily accommodating an animal to be anesthetized, imaged or otherwise treated, (b) an imaging treating and/or device useful for imaging or otherwise treating said animal; and (c) a bridging mechanism in connection with said chamber and said device.