Therapeutic methods using adipose tissue-derived cell suspensions comprising adipocytes
Provided herein is a use of an adipose tissue-derived cell suspension which comprises adipocytes for the preparation of a pharmaceutical composition for use in the treatment of an inflammatory disorder, a cartilage or bone disorder and/or the alleviation of pain associated with an inflammatory disorder in a mammalian subject. Also provided herein is a method of treating an inflammatory disorder, a cartilage or bone disorder or alleviating pain associated with an inflammatory disorder in a mammalian subject, comprising administering to the subject a pharmaceutical composition which comprises: (i) an adipose tissue-derived cell suspension which comprises adipocytes; or (ii) a cell-free extract which is prepared from an adipose tissue-derived cell suspension, wherein the adipose tissue-derived cell suspension comprises adipocytes, together with a pharmaceutically-acceptable carrier or diluent.
1. A method for treating an inflammatory disorder or a cartilage disorder or alleviating pain associated with an inflammatory disorder in a subject, comprising the step of administering to the subject a pharmaceutical composition comprising a cell free extract prepared from an adipose tissue-derived cell suspension comprising adipocytes and adipose-derived non-adipocyte cells.
2. The method according to claim 1 , wherein the adipose tissue-derived cell suspension is freshly isolated.
3. The method according to claim 1 , wherein the adipose tissue-derived cell suspension is autologous to the subject.
4. The method use according to claim 1 , wherein the adipose tissue-derived cell suspension is allogeneic to the subject.
5. The method according to claim 1 , wherein the subject is a human.
6. The method according to claim 1 , wherein the pharmaceutical composition is a veterinary composition and the subject is a non-human mammal.
7. The method according to claim 1 , wherein the inflammatory disorder is selected from a joint-related inflammatory disorder, corneal inflammation, or skin inflammation.