Method for combating adverse effects arising from antipsychotic treatment
This invention relates to a method for combating adverse effects arising from antipsychotic treatment. The invention furthermore relates to novel pharmaceutical compositions comprising a therapeutically effective combination of a compound of formula I and an antipsychotic drug.
1. A method of treatment or alleviation of an adverse effect arising from a previous antipsychotic treatment comprising
administering to a living animal body a combination of
a therapeutically effective amount of [(1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-azabicyclo[3.2.1]octane, or a pharmaceutically acceptable salt thereof; and
a therapeutically effective amount of an antipsychotic drug, or a pharmaceutically acceptable salt thereof;
wherein the combination is effective in treating or alleviating weight gain associated with the previous antipsychotic treatment.
2. The method of claim 1 , wherein the antipsychotic drug combined with a therapeutically effective amount of [(1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-azabicyclo[3.2.1]octane, or a pharmaceutically acceptable salt thereof is olanzapine or a pharmaceutically acceptable salt thereof.
3. The method of claim 1 , wherein the living animal body is a human.
4. The method of claim 1 , wherein:
the adverse effect is weight gain;
the previous antipsychotic treatment is treatment with olanzapine or a pharmaceutically acceptable salt thereof; and
the living animal body is a human.
5. The method of claim 1 , wherein the [(1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-azabicyclo[3.2.1]octane, or pharmaceutically acceptable salt thereof; and the antipsychotic drug, or pharmaceutically acceptable salt thereof, are administered simultaneously, sequentially, or separately.
6. The method of claim 1 , wherein the previous antipsychotic treatment is treatment with amisulpride, aripiprazole, asenapine, bifeprunox, clozapine, iloperidone, melperone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, ziprasidone, or zotepine, or a pharmaceutically acceptable salt thereof.
7. The method of claim 1 , wherein the previous antipsychotic treatment is treatment with olanzapine.
8. The method of claim 1 , wherein the previous antipsychotic treatment is treatment with clozapine.
9. The method of claim 6 , wherein the antipsychotic drug combined with a therapeutically effective amount of [(1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-azabicyclo[3.2.1]octane, or a pharmaceutically acceptable salt thereof is amisulpride, aripiprazole, asenapine, bifeprunox, clozapine, iloperidone, melperone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, ziprasidone, or zotepine, or a pharmaceutically acceptable salt thereof.
10. The method of claim 7 , wherein the antipsychotic drug combined with a therapeutically effective amount of [(1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-azabicyclo[3.2.1]octane, or a pharmaceutically acceptable salt thereof is olanzapine or a pharmaceutically acceptable salt thereof.
11. The method of claim 8 , wherein the antipsychotic drug combined with a therapeutically effective amount of [(1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-azabicyclo[3.2.1]octane, or a pharmaceutically acceptable salt thereof is clozapine or a pharmaceutically acceptable salt thereof.