Optical force based biomolecular analysis in slot waveguides
An architecture for the handling and transport of nanoscopic matter in lab on a chip devices using optical forces. A slot waveguide is used to focus and harness optical energy to trap and transport nanoscale objects. The slot waveguide is a unique structure that has several advantageous features, such as high optical confinement, and enables nanoparticles to interact fully with a propagating optical mode.
1. A system comprising:
a slot waveguide containing a slot providing high optical confinement and forming a channel for transport of at least one particle, wherein the slot is sandwiched between two walls, a refractive index of the two walls being greater than a refractive index of the slot;
a channel outside the slot waveguide and coupled to the slot waveguide for providing a fluid having particles to the slot; and
an optical power source to provide optical power to the slot waveguide to exert first optical forces transverse to the slot to trap the particles within the slot of the slot waveguide.
2. The system of claim 1 wherein the channel provides fluid flowing transverse to the slot.
3. The system of claim 1 wherein the slot is between 40 nm and 200 nm in width.
4. The system of claim 1 wherein the particles comprise at least partially uncoiled proteins or DNA.
5. The system of claim 1 wherein the optical power is to exert second optical forces along the slot to transport the particles along the slot.
6. The system of claim 1 wherein the optical power is concentrated in an eigenmode in the slot.
7. The system of claim 1 and further comprising a cover positioned over at least a portion of a length of the slot.
8. A method comprising:
providing fluid containing particles to a slot waveguide by using a channel outside the slot waveguide and coupled to the slot waveguide;
providing optical power to the slot waveguide to exert first optical forces transverse to a slot of the slot waveguide on the particles to trap the particles within the slot of the slot waveguide, wherein the slot is sandwiched between two walls, and wherein a refractive index of the two walls is greater than a refractive index of the slot, and wherein the slot provides high optical confinement and forms a channel within the slot for transport of at least one particle.
9. The method of claim 8 wherein the particles are released from the slot when optical power is removed.
10. The method of claim 8 wherein the particles in the slot are transported along the slot by second optical forces along the slot exerted by the optical power.
11. The method of claim 8 wherein the optical power is confined in the slot in an eigenmode of propagation.
12. The method of claim 8 wherein particles are fluidically transported into the slot through longitudinal fluid flow.