IP Library › Granted Patent US 8,481,499
Granted Patent B2
US 8,481,499 · App. 13/066,930 · Granted Jul 9, 2013

Blockade of gamma-secretase activity to promote myelination by oligodendrocytes

Inventors: Trent Alan Watkins (Palo Alto, CA); Ben A. Barres (Palo Alto, CA)
Assignee: The Board of Trustees of the Leland Stanford Junior University
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,481,499
App. No.
13/066,930
Granted
Jul 9, 2013
Kind
B2
Abstract

Methods are provided for enhancing myelination. Myelination is enhanced by administration of agents that are inhibitors of γ-secretase. Methods of screening for pharmaceutically active compounds that enhance myelination, and for genes involved in myelination are also provided.

Claims (7)

1. A method of enhancing CNS myelination in a patient having a CNS disorder characterized by a myelin deficiency, the method comprising:

contacting an oligodendrocyte or progenitor thereof in the proximity of an axon in a patient having a CNS disorder characterized by a myelin deficiency with an effective dose of an inhibitor of γ-secretase;

wherein the myelination of said axon is enhanced in said patient.

2. The method according to claim 1 , wherein said inhibitor of γ-secretase is a genetic agent.

3. The method according to claim 1 , wherein said inhibitor of γ-secretase is a pharmacologic agent.

4. The method according to claim 1 , wherein said CNS disorder characterized by a myelin deficiency is a demyelinating disorder.

5. The method according to claim 4 , wherein said demyelinating disorder is multiple sclerosis.

Assignments (2)
CONFIRMATORY LICENSE Recorded Oct 24, 2011
From: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 027111/0504 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 21, 2011
From: WATKINS, TRENT ALAN; BARRES, BEN A.
To: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Reel/Frame 026944/0405 →
Continuity (3)
Continuation 11705909 · Feb 13, 2007
Provisional Application 60773191 · Feb 13, 2006
Related Publication 20110251133A1 · Oct 13, 2011