Human LY6-Big Molecules and Methods of Use
The present invention is directed to human Ly6-BIG molecules and their use in diagnostic, prognostic, and treatment methods for colon, lung and other cancers, in preventing the reoccurrence of such cancers, and in diagnostic, prognostic, and treatment methods for autoimmune disorders and AIDS.
1 . An isolated polynucleotide comprising a nucleic acid at least 85%, 90% or 95% identical to a nucleotide sequence in SEQ ID NOs: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, or 37.
2 . An isolated polynucleotide comprising a nucleic acid encoding a polypeptide at least 85%, 90% or 95% identical to the amino acid sequence in SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, or 38.
3 . A fragment of the polynucleotide of claim 1 or claim 2 .
4 . A polypeptide encoded by the polynucleotide of any of claims 1 - 3 .
5 . The polypeptide of claim 4 , which is 100% identical to the amino acid sequence in SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, or 38.
6 . A host cell comprising the polynucleotide of any of claims 1 - 3 .
7 . An antibody that specifically binds the polypeptide of claim 4 or claim 5 .
8 . A composition comprising the polynucleotide of any of claims 1 - 3 , the polypeptide of claim 4 or claim 5 , or the antibody of claim 7 .
9 . A method of treating autoimmune disorders or cancer in a patient in need thereof, comprising administering the antibodies of claim 7 to said patient or to cells derived from said patient.