Methods of improving the appearance of aging skin

1. A method of improving the appearance of aging skin comprising: applying to skin tissue having dullness or lack of radiance, a safe and effective amount of a composition containing S-acyl glutathione derivative of formula (I);

and a dermatologically acceptable carrier;

in a sufficient amount and for a sufficient time to improve the dullness or lack of radiance of the skin tissue.

2. The method of claim 1 , wherein the composition comprises about 0.01% to about 20% by weight of S-palmitoyl glutathione derivative.

3. The method of claim 2 , wherein the composition comprises about 0.1% to about 5% by weight of S-palmitoyl glutathione derivative.

4. The method of claim 3 , wherein the composition comprises about 1.0% to about 3% by weight of S-palmitoyl glutathione.

5. The method of claim 1 , wherein the composition further comprises one or more additional ingredients selected from the group consisting of: ascorbic acid, ascorbic acid derivatives, lipoic acid, neuropeptides, α-hydroxy acids, salts of magnesium, zinc and copper, tocotrienols, tocotrienol derivatives and vitamin E compositions enriched with tocotrienols or tocotrienol derivatives.

6. The method of claim 1 , wherein the skin tissue also has dryness.

7. The method of claim 1 , wherein the skin tissue also has wrinkles and lines.

8. The method of claim 1 , wherein the skin tissue also has enlarged pores.

9. The method of claim 1 , wherein the skin tissue is peri-menopausal, menopausal, or post-menopausal skin.

10. A method of treating marionette lines to improve the appearance thereof, comprising: applying to human skin tissue having marionette lines a safe and effective amount of a composition containing S-acyl glutathione derivative of formula (I);

and a dermatologically acceptable carrier;

in a sufficient amount and for a sufficient time to improve the appearance of the marionette lines.

11. The method of claim 10 , wherein the composition comprises about 0.01% to 20% by weight of S-palmitoyl glutathione derivative.

12. The method of claim 11 , wherein the composition comprises about 0.1% to 5% by weight of S-palmitoyl glutathione derivative.

13. The method of claim 12 , wherein the composition comprises about 1.0% to 3% by weight S-palmitoyl glutathione.

14. The method of claim 10 , wherein the composition further comprises one or more additional ingredients selected from the group consisting of: ascorbic acid , ascorbic acid derivatives, lipoic acid, neuropeptides, α-hydroxy acids, salts of magnesium, zinc and copper, tocotrienols , tocotrienol derivatives and vitamin E compositions enriched with tocotrienols or tocotrienol derivatives.

15. The method of claim 10 , wherein the skin tissue also has additional lines and wrinkles and the method treats the additional lines and wrinkles .

16. The method of claim 15 , wherein the additional lines and wrinkles comprises eleven lines.

17. The method of claim 15 , wherein the additional lines and wrinkles comprise horizontal forehead lines.

18. The method of claim 10 , wherein the skin tissue also has sagging skin and the method improves the appearance thereof.

19. The method of claim 10 , wherein the skin tissue also has dryness and the method improves the appearance thereof.

20. The method of claim 10 , wherein the skin tissue also has discoloration and the method improves the appearance thereof.

21. The method of claim 10 , wherein the skin tissue also has redness or blotchiness and the method improves the appearance thereof.

22. The method of claim 21 , wherein the redness or blotchiness is comprised of spider vessels.

23. The method of claim 10 , wherein the skin is peri-menopausal, menopausal, or post-menopausal skin.

24. A method of treating eleven lines to improve the appearance thereof comprising: applying to human skin tissue having eleven lines, a safe and effective amount of a composition containing S-acyl glutathione derivative of formula (I):

and a dermatologically acceptable carrier;

in a sufficient amount and for a sufficient time to improve the appearance of the eleven lines.

25. The method of claim 24 , wherein the composition comprises about 0.01% to 20% by weight of S-palmitoyl glutathione derivative.

26. The method of claim 25 , wherein the composition comprises about 0.1% to 5% by weight of S-palmitoyl glutathione derivative.

27. The method of claim 26 , wherein the composition comprises about 1.0% to 3% by weight S-palmitoyl glutathione.

28. The method of claim 24 , wherein the skin tissue is peri-menopausal, menopausal, or post-menopausal skin.

29. A method of treating horizontal forehead lines to improve the appearance thereof comprising: applying to human skin tissue having horizontal forehead lines, a safe and effective amount of a composition containing S-acyl glutathione derivative of formula (I):

and a dermatologically acceptable carrier;

in a sufficient amount and for a sufficient time to improve the appearance of the horizontal forehead lines.

30. The method of claim 29 , wherein the composition comprises about 0.01% to 20% by weight of S-palmitoyl glutathione derivative.

31. The method of claim 30 , wherein the composition comprises about 0.1% to 5% by weight of S-palmitoyl glutathione derivative.

32. The method of claim 31 , wherein the composition comprises about 1.0% to 3% by weight S-palmitoyl glutathione.

33. The method of claim 29 , wherein the skin tissue is peri-menopausal, menopausal, or post-menopausal skin.

34. A method of treating sagging skin to improve the appearance thereof comprising: applying to human skin tissue having sagging skin, a safe and effective amount of a composition containing S-acyl glutathione derivative of formula (I):

and a dermatologically acceptable carrier;

in a sufficient amount and for a sufficient time to improve the appearance of the sagging skin.

35. The method of claim 34 , wherein the composition comprises about 0.01% to 20% by weight of S-palmitoyl glutathione derivative.

36. The method of claim 35 , wherein the composition comprises about 0.1% to 5% by weight of S-palmitoyl glutathione derivative.

37. The method of claim 36 , wherein the composition comprises about 1.0% to 3% by weight S-palmitoyl glutathione.

38. The method of claim 34 , wherein the skin tissue is peri-menopausal, menopausal, or post-menopausal skin.

39. A method of treating spider vessels in red or blotchy skin to improve the appearance thereof comprising: applying to human skin tissue having spider vessels in red or blotchy skin, a safe and effective amount of a composition containing S-acyl glutathione derivative of formula (I):

and a dermatologically acceptable carrier;

in a sufficient amount and for a sufficient time to improve the appearance of the spider vessels in red or blotchy skin.

40. The method of claim 39 , wherein the composition comprises about 0.01% to 20% by weight of S-palmitoyl glutathione derivative.

41. The method of claim 40 , wherein the composition comprises about 0.1% to 5% by weight of S-palmitoyl glutathione derivative.

42. The method of claim 41 , wherein the composition comprises about 1.0% to 3% by weight S-palmitoyl glutathione.

43. The method of claim 39 , wherein the skin tissue is peri-menopausal, menopausal, or post-menopausal skin.

44. A method of treating enlarged pores to improve the appearance thereof comprising: applying to human skin tissue having enlarged pores, a safe and effective amount of a composition containing S-acyl glutathione derivative of formula (I):

and a dermatologically acceptable carrier

in a sufficient amount and for a sufficient time to improve the appearance of the enlarged pores.

45. The method of claim 44 , wherein the composition comprises about 0.01% to 20% by weight of S-palmitoyl glutathione derivative.

46. The method of claim 45 , wherein the composition comprises about 0.1% to 5% by weight of S-palmitoyl glutathione derivative.

47. The method of claim 46 , wherein the composition comprises about 1.0% to 3% by weight S-palmitoyl glutathione.

48. The method of claim 44 , wherein the skin tissue is peri-menopausal, menopausal, or post-menopausal skin.

49. A method of treating skin which is dull and lacking radiance to improve the appearance thereof comprising: applying to human skin tissue which is dull and lacking radiance, a safe and effective amount of a composition containing S-acyl glutathione derivative of formula (I):

and a dermatologically acceptable carrier

in a sufficient amount and for a sufficient time to improve the appearance of the skin which is dull and lacking in radiance.

50. The method of claim 49 , wherein the composition comprises about 0.01% to 20% by weight of S-palmitoyl glutathione derivative.

51. The method of claim 50 , wherein the composition comprises about 0.1% to 5% by weight of S-palmitoyl glutathione derivative.

52. The method of claim 51 , wherein the composition comprises about 1.0% to 3% by weight S-palmitoyl glutathione.

53. The method of claim 49 , wherein the skin tissue is peri-menopausal, menopausal, or post-menopausal skin.

54. A method of improving the appearance of aging skin comprising: applying to skin tissue having enlarged pores, a safe and effective amount of a composition containing S-acyl glutathione derivative of formula (I)

and a dermatologically acceptable carrier;

in a sufficient amount and for a sufficient time to improve the appearance of the enlarged pores.

55. The method of claim 54 , wherein the composition comprises about 0.01% to 20% by weight of S-palmitoyl glutathione derivative.

56. The method of claim 55 , wherein the composition comprises about 0.1% to 5% by weight of S-palmitoyl glutathione derivative.

57. The method of claim 56 , wherein the composition comprises about 1.0% to 3% by weight S-palmitoyl glutathione.

58. The method of claim 54 , wherein the skin tissue is peri-menopausal, menopausal, or post-menopausal skin.

59. A method of improving the appearance of aging skin comprising: applying to skin tissue having marionette lines, a safe and effective amount of a composition containing S-acyl glutathione derivative of formula (I)

and a dermatologically acceptable carrier;

in a sufficient amount and for a sufficient time to improve the appearance of the marionette lines.

60. The method of claim 59 , wherein the composition comprises about 0.01% to 20% by weight of S-palmitoyl glutathione derivative.

61. The method of claim 60 , wherein the composition comprises about 0.1% to 5% by weight of S-palmitoyl glutathione derivative.

62. The method of claim 61 , wherein the composition comprises about 1.0% to 3% by weight S-palmitoyl glutathione.

63. The method of claim 59 , wherein the skin tissue is peri-menopausal, menopausal, or post-menopausal skin.

64. A method of improving the appearance of aging skin comprising: applying to skin tissue having eleven lines, a safe and effective amount of a composition containing S-acyl glutathione derivative of formula (I)

and a dermatologically acceptable carrier;

in a sufficient amount and for a sufficient time to improve the appearance of the eleven lines.

65. The method of claim 64 , wherein the composition comprises about 0.01% to 20% by weight of S-palmitoyl glutathione derivative.

66. The method of claim 65 , wherein the composition comprises about 0.1% to 5% by weight of S-palmitoyl glutathione derivative.

67. The method of claim 66 , wherein the composition comprises about 1.0% to 3% by weight S-palmitoyl glutathione.

68. The method of claim 64 , wherein the skin tissue is peri-menopausal, menopausal, or post-menopausal skin.

69. A method of improving the appearance of aging skin comprising: applying to skin tissue having horizontal forehead lines, a safe and effective amount of a composition containing S-acyl glutathione derivative of formula (I)

and a dermatologically acceptable carrier;

in a sufficient amount and for a sufficient time to improve the appearance of the horizontal forehead lines.

70. The method of claim 69 , wherein the composition comprises about 0.01% to 20% by weight of S-palmitoyl glutathione derivative.

71. The method of claim 70 , wherein the composition comprises about 0.1% to 5% by weight of S-palmitoyl glutathione derivative.

72. The method of claim 71 , wherein the composition comprises about 1.0% to 3% by weight S-palmitoyl glutathione.

73. The method of claim 69 , wherein the skin tissue is peri-menopausal, menopausal, or post-menopausal skin.

74. A method of improving the appearance of aging skin comprising: applying to skin tissue having sagging skin, a safe and effective amount of a composition containing S-acyl glutathione derivative of formula (I)

and a dermatologically acceptable carrier;

in a sufficient amount and for a sufficient time to improve the appearance of the sagging skin.

75. The method of claim 74 , wherein the composition comprises about 0.01% to 20% by weight of S-palmitoyl glutathione derivative.

76. The method of claim 75 , wherein the composition comprises about 0.1% to 5% by weight of S-palmitoyl glutathione derivative.

77. The method of claim 76 , wherein the composition comprises about 1.0% to 3% by weight S-palmitoyl glutathione.

78. The method of claim 74 , wherein the skin tissue is peri-menopausal, menopausal, or post-menopausal skin.

79. A method of improving the appearance of aging skin comprising: applying to skin tissue having spider vessels in red or blotchy skin, a safe and effective amount of a composition containing S-acyl glutathione derivative of formula (I)

and a dermatologically acceptable carrier;

in a sufficient amount and for a sufficient time to improve the appearance of the spider vessels in the red or blotchy skin.

80. The method of claim 79 , wherein the composition comprises about 0.01% to 20% by weight of S-palmitoyl glutathione derivative.

81. The method of claim 80 , wherein the composition comprises about 0.1% to 5% by weight of S-palmitoyl glutathione derivative.

82. The method of claim 81 , wherein the composition comprises about 1.0% to 3% by weight S-palmitoyl glutathione.

83. The method of claim 79 , wherein the skin tissue is peri-menopausal, menopausal, or post-menopausal skin.