Skin Hyperpigmentation Acyl Glutathione Treatments
Topical compositions for treatment of hyperpigmentation comprise an effective amount of S-acyl glutathione derivative and a carrier. Methods for treating hyperpigmentation, such as melasma, postinflammatory hyperpigmentation and lentigines, skin lightening and skin whitening comprise applying a composition containing S-acyl glutathione derivative in a dermatologically acceptable carrier to skin tissue. The acyl group is a saturated or unsaturated aliphatic C 12 -C 24 group, preferably a C 16 -C 24 group, most preferably a C 16 group. In particularly preferred embodiments, the S-acyl glutathione derivative is S-palmitoyl glutathione.
1 . A topical composition for treatment of hyperpigmentation, comprising:
an effective amount of S-acyl glutathione derivative of formula (I)
wherein R 1 consists of a saturated or unsaturated aliphatic C 12 -C 24 group and R 2 is a hydrogen, aliphatic or aromatic acyl group; and
a dermatologically acceptable carrier.
2 . The composition of claim 1 , wherein R 1 is a C 16 -C 20 group.
3 . The composition of claim 2 , wherein R 1 is a palmitoyl group.
4 . The composition of claim 1 , comprising from about 0.01% to about 20% by weight of S-acyl glutathione derivative.
5 . The composition of claim 5 , comprising from about 0.1% to about 10% by weight of S-acyl glutathione derivative.
6 . The composition of claim 5 , comprising from about 3.0% to about 9.0% by weight S-acyl glutathione derivative.
7 . The composition of claim 1 , wherein the carrier comprises fatty acid derivatives of stearic acid.
8 . The composition of claim 1 , further comprising one or more additional ingredients selected from the group consisting of: ascorbic acid and ascorbic acid derivatives, lipoic acid, α-hydroxy acids, and salts of magnesium, zinc and copper, and mixtures thereof.
9 . A method for the treatment of hyperpigmentation comprising: applying a composition containing S-acyl glutathione derivative of formula (I)
wherein R 1 consists of a saturated or unsaturated aliphatic C 12 -C 24 group and R 2 is a hydrogen, aliphatic or aromatic acyl group; and a dermatologically acceptable carrier; to skin tissue.
10 . The method of claim 9 , wherein R 1 is a C 16 -C 20 group.
11 . The method of claim 10 , wherein R 1 is a palmitoyl group.
12 . The method of claim 9 , wherein the composition comprises from about 0.01% to about 20% by weight of S-acyl glutathione derivative.
13 . The method of claim 12 , wherein the composition comprises from about 0.1% to about 10% by weight of S-acyl glutathione derivative.
14 . The method of claim 13 , wherein the composition comprises from about 3.0% to about 9.0% by weight of S-acyl glutathione derivative.
15 . The method of claim 9 , wherein the carrier comprises fatty acid derivatives of stearic acid.
16 . The method of claim 9 , wherein the composition further comprises one or more additional ingredients selected from the group consisting of: ascorbic acid and ascorbic acid derivatives, lipoic acid, α-hydroxy acids, and salts of magnesium, zinc and copper, and mixtures thereof.
17 . The method of claim 9 , wherein the hyperpigmentation comprises facial hyperpigmentation.
18 . The method of claim 17 , wherein the hyperpigmentation comprises at least one of melasma, postinflammatory hyperpigmentation and lentigines.
19 . A method for skin lightening comprising applying a composition containing S-palmitoyl glutathione and a dermatologically acceptable carrier to skin tissue.
20 . A method for skin whitening comprising applying a composition containing S-palmitoyl glutathione and a dermatologically acceptable carrier to skin tissue.