Sweet flavor modifier

1. A compound of claim having a structural Formula (IIIa) or (IIIa'),

or a tautomer, and/or salt thereof, wherein:

A is —NH 2;

B is hydrogen, alkyl, —CN, —OR 4 , —S(O) a R 4 , —NR 4 R 5 , —C(O)NR 4 R 5 , —CO 2 R 4 , —NR 4 CO 2 R 5 , —NR 4 C(O)NR 5 R 6 , —NR 4 C(S)NR 5 R 6 , —NR 4 C(═NH)NR 5 R 6 , —SO 2 NR 4 R 5 , —NR 4 SO 2 R 5 , —NR 4 SO 2 NR 5 R 6 , —B(OR 4 )(OR 5 ), —P(O)(OR 4 )(OR 5 ), or —P(O)(R 4 )(OR 5 );

C is —CO 2 R 7 ;

a is 0, 1 or 2;

R 4 , R 5 , R 6 , and R 7 are independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, acyl, substituted acyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl; or alternatively, R 4 and R 5 , or R 5 and R 6 , together with the atoms to which they are bonded, form a cycloheteroalkyl or substituted cycloheteroalkyl ring

R 21 is hydrogen;

R 22 is hydrogen, alkyl, substituted alkyl, halo, —CN, or —OR 27 ;

R 23 is hydrogen, alkyl, substituted alkyl, —CN, —OR 29 , —S(O) f R 29 , —OC(O)R 29 , —NR 29 R 30 , —C(O)NR 29 R 30 , —C(O)R 29 , —CO 2 R 29 , —SO 2 NR 29 R 30 , or —NR 29 SO 2 R 30 ;

R 24 is —O-L 1 -L 2 -R 33 or —OR 33 ;

L 1 is alkylene or substituted alkylene;

L 2 is —NR 34 —,—O—, —S—, —NR 34 —C(O)—, —C(O)—NR 34 —, —O—C(O)—, —C(O)—O—, —NR 34 —C(O)—O—, —O—C(O)—NR 34 —,—NR 34 —C(O)—NR 35 —, —O—C(O)—O—,-heterocyclylene-C(O)—, or -(substituted heterocyclylene)-C(O)—;

R 33 is alkyl, substituted alkyl, carbocyclyl, substituted carbocyclyl; aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocyclyl, substituted heterocyclvl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl;

R 34 and R 35 are independently hydrogen, alkyl, substituted alkyl, carbocyclyl, substituted carbocyclyl; aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocyclyl, substituted heterocyclyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl;

f and g are independently 0, 1 or 2; and

R 27 , R 29 , and R 30 are independently hydrogen, or alkyl;

wherein substituted, when used to modify a specified group or radical, means that one or more hydrogen atoms of the specified group or radical are each independently replaced with one or more substituent group(s);

wherein substituent groups on saturated carbon atoms in the substituted group or radical include one or more of —R a , halo, —O − , ═O, —OR b , —SR b , —S − , ═S, —NR c R c , ═NR b , ═N—OR b , trihalomethyl, —CF 3 , —CN, —OCN, —SCN, —NO, —NO 2 , ═N 2 , —N 3 , —S(O) 2 R b , —S(O) 2 NR b , —S(O) 2 O − , —S(O) 2 OR b , —OS(O) 2 R b , —OS(O) 2 O − , —OS(O) 2 OR b , —P(O)(O − ) 2 , —P(O)(OR b )(O − ), —P(O)(OR b )(OR b ), —C(O)R b , —C(S)R b , —C(NR b )R b , —C(O)O − , —C(O)OR b , —C(S)OR b , —C(O)NR c R c , —C(NR b )NR c R c , —OC(O)R b , —OC(S)R b , —OC(O)O − , —OC(O)OR b , —OC(S)OR b , —NR b C(O)R b , —NR b C(S)R b , —NR b C(O)O − , —NR b C(O)OR b , —NR b C(S)OR b , —NR b C(O)NR c R c , —NR b C(NR b )R b or —NR b C(NR b )NR c R c ,

wherein each R a is independently selected from the group consisting of alkyl, cycloalkyl, heteroalkyl, cycloheteroalkyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl; each R b is independently hydrogen or R a ; and each R c is independently R b or alternatively, the two R c s may be taken together with the nitrogen atom to which they are bonded form a 4-, 5-, 6- or 7-membered cycloheteroalkyl which may optionally include from 1 to 4 of the same or different additional heteroatoms selected from the group consisting of O, N and S;

wherein the one or more substituent groups, taken together with the atoms to which they are bonded, may form a cyclic ring including cycloalkyl and cycloheteroalkyl;

wherein substituent groups on unsaturated carbon atoms in the specified group or radical include —R a , halo, —O − , —OR b , —SR b , —S − , —NR c R c , trihalomethyl, —CF 3 , —CN, —OCN, —SCN, —NO, —NO 2 , —N 3 , —S(O) 2 ,R b , —S(O) 2 O − , —S(O) 2 OR b , —OS(O) 2 R b , —OS(O) 2 O − , —OS(O) 2 OR b , —P(O)(O − ) 2 , —P(O)(OR b )(O − ), —P(O)(OR b )(OR b ), —C(O)R b , —C(S)R b , —C(NR b )R b , —C(O)O − , —C(O)OR b , —C(S)OR b , —C(O)NR c R c , —C(NR b )NR c R c , —OC(O)R b , —OC(S)R b , —OC(O)O − , —OC(O)OR b , —OC(S)OR b , —NR b C(O)R b , —NR b C(S)R b , —NR b C(O)O − , —NR b C(O)OR b , —NR b C(S)OR b , —NR b C(O)NR c R c , —NR b C(NR b )R b or —NR b C(NR b )NR c R c ;

wherein substituent groups on nitrogen atoms in heteroatom-containing groups include —R a , —O − , —OR b , —SR b , —S − , —NR c R c , trihalomethyl, —CF 3 , —CN, —NO, —NO 2 , —S(O) 2 R b , —S(O) 2 O − , —S(O) 2 OR b , —OS(O) 2 R b , —OS(O) 2 O − , —OS(O) 2 OR b , —P(O)(O − ) 2 , —P(O)(OR b )(O − ), —P(O)(OR b )(OR b ), —C(O)R b , —C(S)R b , —C(NR b )R b , —C(O)OR b , —C(S)OR b , —C(O)NR c R c , —C(NR b )NR c R c , —OC(O)R b , —OC(S)R b , —OC(O)OR b , —OC(S)OR b , —NR b C(O)R b , —NR b C(S)R b , —NR b C(O)OR b , —NR b C(S)OR b , —NR b C(O)NR c R c , —NR b C(NR b )R b or —NR b C(NR b )NR c R c ; and

wherein substituents used to substitute a specified group can be further substituted with one or more of the same or different substituent groups.

2. The compound of claim 1 , wherein R 21 , R 22 , and R 23 are all hydrogen.

3. The compound of claim 1 , wherein R 21 and R 22 are all hydrogen.

4. The compound of claim 1 having a structural Formula (IIIb) or (IIIb'),

or a tautomer, and/or salt thereof; wherein

L l is alkylene or substituted alkylene;

L 2 is —NR 34 —, —O—, —S—, —NR 34 —C(O)—, —C(O)—NR 34 —, —O—C(O)—, —C(O)—O—, —NR 34 —C(O)—O—, —O—C(O)—NR 34 —,—NR 34 —C(O)—NR 35 —, —O—C(O)—O—, -heterocyclylene-C(O)—, or -(substituted heterocyclylene)-C(O)—;

R 33 is alkyl, substituted alkyl, carbocyclyl, substituted carbocyclyl; aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocyclyl, substituted heterocyclyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl; and

R 34 and R 35 are independently hydrogen, alkyl, substituted alkyl, carbocyclyl, substituted carbocyclyl; aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocyclyl, substituted heterocyclyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl.

5. The compound of claim 1 having a structural Formula (IIIc), or (IIIc'),

or a tautomer, and/or salt, thereof; wherein

R 33 is alkyl, substituted alkyl, carbocyclyl, substituted carbocyclyl; aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocyclyl, substituted heterocyclyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl.

6. The compound of claim 5 , wherein

R 33 is alkyl, substituted alkyl, carbocyclyl, substituted carbocyclyl; heterocyclyl, substituted heterocyclyl, heteroalkyl, or substituted heteroalkyl.

7. The compound of claim 4 , wherein

A is —NH 2 ;

B is hydrogen, or alkyl;

C is —CO 2 R 7 ;

L 1 is alkylene or substituted alkylene;

L 2 is —NR 34 —, —O—, —NR 34 —C(O)—, —C(O)—NR 34 —, —O—C(O)—, —C(O)—O—, -hetercyclylene-C(O)—, or -(substituted hetercyclylene)-C(O)—;

R 33 is alkyl, substituted alkyl, carbocyclyl, substituted carbocyclyl; aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocyclyl, substituted heterocyclyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, or substituted heteroarylalkyl; and

R 34 and R 35 are independently hydrogen, alkyl, or substituted alkyl.

8. The compound of claim 5 , wherein

A is —NH 2 ;

B is hydrogen, or alkyl;

C is —CO 2 R 7 ;

R 33 is alkyl, substituted alkyl, carbocyclyl, substituted carbocyclyl; heterocyclyl, substituted heterocyclyl, heteroalkyl, or substituted heteroalkyl.

9. The compound of claim 1 , which is selected from the group consisting of

10. The compound of claim 1 , which is selected from the group consisting of

or a tautomer, and/or salt, thereof.