Indole antiviral compositions and methods
View Patent ↗The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.
1. A compound as depicted in formula (I), wherein the formula (I) is as follows:
wherein R 1 is i) a 1-D ribosyl substituent; ii) the 2-deoxy derivative of said substituent; or iii) the α or β-anomer of said substituent;
wherein R 2 is selected from the group consisting of
chloro, bromo,
wherein R 3 is selected from the group consisting of
wherein R 4 and R 7 are independently selected from H, Cl, Br, F, I, a nitro group, and an azido group;
where R 8 and R 9 are independently selected from H, CH 3 , C 2 H 5 , isopropyl, and cyclopropyl;
where R 10 is H, CH 3 , C 2 H 5 , or CH 2 C 6 H 5 ; and
where R 11 is H, CH 3 , C 2 H 5 , or CH 2 C 6 H 5 .
2. The compound of claim 1 , wherein said compound is selected from the group consisting of:
3. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier or one or more pharmaceutically acceptable excipients.