Prevention and treatment of sub-clinical PCVD
The present invention relates to the use of an immunogenic composition comprising a porcine circovirus type 2 (PCV2) antigen for the prevention and treatment of sub-clinical PCV2 infection in animals, preferably in pigs.
1. A method for the prophylaxis and treatment of a sub-clinical PCV2 infection in an individual pig or a group of pigs, comprising the step of administering an immunogenic composition comprising a PCV2 ORF2 antigen to a pig in need of such administration, wherein the sub-clinical PCV2 infection is characterized by individual infected pigs having at or below 10 6 viral copies of PCV2 per ml of serum for at least 6 weeks in the absence of one or more clinical symptoms of PCVD and wherein the subclinical infection is characterized by a group or herd of pigs having 20% or fewer pigs of the herd with more than 10 6 viral copies of PCV2 per ml of serum.
2. The method according to claim 1 , wherein the sub-clinical PCV2 infection is further characterized by a virus persistence in the herd of at least 6 weeks.
3. The method according to claim 1 , wherein the sub-clinical PCV2 infection is further characterized by no morbidity or a low morbidity rate of less than 25% of the PCV2 positive pigs within a herd.
4. The method according to claim 1 , wherein the sub-clinical PCV2 infection is further characterized by low mortality rate of less than 20% of the PCV2 positive pigs within a herd.
5. The method according to claim 1 , wherein the PCV2 ORF2 antigen is a polypeptide having at least 80% identity with SEQ ID NO: 9 or SEQ ID NO: 10.
6. The method of claim 1 , wherein the PCV2 antigen is a polypeptide having at least 90% identity with SEQ ID NO: 9 or SEQ ID NO: 10.
7. The method according to claim 1 , wherein the PCV2 ORF2 antigen is a recombinant baculovirus expressed ORF2 of PCV2.
8. The method according to claim 1 , wherein the PCV2 ORF2 antigen is Ingelvac® CircoFLEX™.
9. A method of treating a pig with PCV2 sub-clinical infection, wherein sub-clinical PCV2 infection is characterized by individual infected pigs having at or below 10 6 viral copies of PCV2 per ml of serum for at least 6 weeks in the absence of one or more clinical symptoms of PCVD and wherein the subclinical infection is characterized by a group or herd of pigs having 20% or fewer pigs of the herd with more than 10 6 viral copies of PCV2 per ml of serum, the method comprising the step of administering an immunogenic composition comprising a PCV2 ORF2 antigen to a pig in need of such administration, wherein the administration reduces an impact of PCV2 subclinical infection selected from the group consisting of growth impairment, nasal shedding, duration of viremia, and combinations thereof and wherein the reduction of an impact of PCV2 sub-clinical infection is in comparison to pigs not receiving PCV2 ORF2 antigen or an immunogenic composition comprising a PCV2 ORF2 antigen.
10. The method according to claim 9 , wherein the PCV2 antigen is a polypeptide having at least 80% identity with SEQ ID NO: 9 or SEQ ID NO: 10.
11. The method of claim 9 , wherein the PCV2 antigen is a polypeptide having at least 90% identity with SEQ ID NO: 9 or SEQ ID NO: 10.
12. The method according to claim 9 , wherein the PCV2 ORF2 antigen is a recombinant baculovirus expressed ORF2 of PCV2.
13. The method according to claim 9 , wherein the PCV2 ORF2 antigen is Ingelvac® CircoFLEX™.
14. A method for the reduction of the number of pigs with viral load above 10 6 genomic copies per ml serum in a group of pigs (herds) sub-clinically infected with PCV2, comprising the step of administering an immunogenic composition comprising a PCV2 ORF2 antigen to a pig in need of such administration.
15. The method according to claim 14 , wherein the PCV2 antigen is a polypeptide having at least 80% identity with SEQ ID NO: 9 or SEQ ID NO: 10.
16. The method of claim 14 , wherein the PCV2 antigen is a polypeptide having at least 90% identity with SEQ ID NO: 9 or SEQ ID NO: 10.
17. The method according to claim 14 , wherein the PCV2 ORF2 antigen is a recombinant baculovirus expressed ORF2 of PCV2.
18. The method according to claim 14 , wherein the PCV2 ORF2 antigen is Ingelvac® CircoFLEX™.