Granted Patent
B2
US 9,006,221 · App. 13/085,824 · Granted Apr 14, 2015
Method of modulating ship activity
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Abstract
A method of treating or preventing an immune disorder, such as graft versus host disease, in a subject. The method includes the administering a SHIP1 inhibitor, such as 3α-aminocholestane, to a subject in need of treatment. Thus, SHIP1 inhibitors taught herein represent a novel class of small molecules that have the potential to enhance allogeneic transplantation, boost innate immunity and improve the treatment of hematologic malignancies.
Claims (1)
1. A method of inhibiting inositol 5-phosphatase (SHIP) in a subject having multiple myeloma, wherein said method comprises administering an effective amount of 3α-aminocholestane (NSC 23922) to said subject in need thereof, wherein SHIP is inhibited by said administration.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 26, 2011
From: KERR, WILLIAM G.
To: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
Reel/Frame 026812/0079 →
CONFIRMATORY LICENSE
Recorded Apr 26, 2011
From: H. LEE MOFFITT CANCER CTR & RESEARCH INS
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 026179/0058 →
Continuity (3)
Continuation
PCTUS2009060457
· Oct 13, 2009
Provisional Application
61104883
· Oct 13, 2008