Antiviral compounds

1. A compound having the structure:

and its pharmaceutically acceptable salts, hydrates, and coordination compounds, wherein:

R 6 is halo or optionally substituted alkyl,

R 1 -R 5 and R 7a -R 9b are selected independently from the group consisting of: hydrogen, halo, cyano, nitro, thio, amino, carboxyl, formyl, and optionally substituted alkyl, alkylcarbonyloxy, arylcarbonyloxy, heteroarylcarbonyloxy, cycloalkylcarbonyloxy, cycloheteroalkylcarbonyloxy, aralkylcarbonyloxy, heteroaralkylcarbonyloxy, (cycloalkyl)alkylcarbonyloxy, (cycloheteroalkyl)alkylcarbonyloxy, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, cycloalkylcarbonyl, cycloheteroalkylcarbonyl, aralkylcarbonyl, heteroaralkylcarbonyl, (cycloalkyl)alkylcarbonyl, (cycloheteroalkyl)alkylcarbonyl, alkylaminocarbonyl, arylaminocarbonyl, aralkylaminocarbonyl, heteroarylaminocarbonyl, heteroaralkylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, cycloalkylcarbonylamino, cycloheteroalkylcarbonylamino, aralkylcarbonylamino, heteroaralkylcarbonylamino, (cycloalkyl)alkylcarbonylamino, (cycloheteroalkyl)alkylcarbonylamino, dialkylamino, arylamino, diarylamino, aralkylamino, diaralkylamino, heteroarylamino, diheteroarylamino, heteroaralkylamino, diheteroaralkylamino, alkylsulfonyl, arylsulfonyl, heteroarylsuonyl, cycloalkylsulfonyl, aralkylcarbonylthiooxy, carbonylthio, heteroaralkylcarbonylthio, (cycloalkyloxy)carbonylthio, (cycloheteroalkyl)alkylcarbonylthio, alkyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, cycloalkyloxycarbonyl, cycloheteroalkyloxycarbonyl, aralkyloxycarbonyloxloxycarbonyl, heteroaralkyloxycarbonyl, (cycloalkyl)alkyloxycarbonyl, (cycloheteroalkyl)alkyloxycarbonyl, iminoalkyl, iminocycloalkyl, iminocycloheteroalkyl, iminoaralkyl, iminoheteroaralkyl, (cycloalkyl)iminoalkyl, and (cycloheteroalkyl)iminoalkyl;

R 10 is hydrogen or optionally substituted alkyl, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, cycloalkylcarbonyl, cycloheteroalkylcarbonyl, aralkylcarbonyl, heteroaralkylcarbonyl, (cycloalkyl)alkylcarbonyl, (cycloheteroalkyl)alkylcarbonyl, alkylaminocarbonyl, arylaminocarbonyl, aralkylaminocarbonyl, heteroarylaminocarbonyl, heteroaralkylaminocarbonyl, alkylsulfonyl, arylsulfonyl, heteroarylsufonyl, cycloalkylsulfonyl, alkyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, cycloalkyloxycarbonyl, cycloheteroalkyloxycarbonyl, aralkyloxycarbonyloxycarbonyl, heteroaralkyloxycarbonyl, (cycloalkyl)alkyloxycarbonyl, and (cycloheteroalkyl)alkyloxycarbonyl;

X 1 is (CR 11 R 11′ ) m , wherein m is either 1 or 2 such that each of R 11 and R 11′ , independently for each value of m, is selected independently from the group consisting of: hydrogen, halo, cyano, nitro, thio, amino, carboxyl, formyl, and optionally substituted alkyl, alkylcarbonyloxy, arylcarbonyloxy, heteroarylcarbonyloxy, cycloalkylcarbonyloxy, cycloheteroalkylcarbonyloxy, aralkylcarbonyloxy, heteroaralkylcarbonyloxy, (cycloalkyl)alkylcarbonyloxy, (cycloheteroalkyl)alkylcarbonyloxy, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, cycloalkylcarbonyl, cycloheteroalkylcarbonyl, aralkylcarbonyl, heteroaralkylcarbonyl, (cycloalkyl)alkylcarbonyl, (cycloheteroalkyl)alkylcarbonyl, alkylaminocarbonyl, arylaminocarbonyl, aralkylaminocarbonyl, heteroarylaminocarbonyl, heteroaralkylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, cycloalkylcarbonylamino, cycloheteroalkylcarbonylamino, aralkylcarbonylamino, heteroaralkylcarbonylamino, (cycloalkyl)alkylcarbonylamino, (cycloheteroalkyl)alkylcarbonylamino, dialkylamino, arylamino, diarylamino, aralkylamino, diaralkylamino, heteroarylamino, diheteroarylamino, heteroaralkylamino, diheteroaralkylamino, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, cycloalkylsulfonyl, aralkylcarbonylthiooxy, carbonylthio, heteroaralkylcarbonylthio, (cycloalkyloxy)carbonylthio, (cycloheteroalkyl)alkylcarbonylthio, alkyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, cycloalkyloxycarbonyl, cycloheteroalkyloxycarbonyl, aralyoxycarbonyloxloxycarbonyl, heteroaralkyloxycarbonyl, (cycloalkyl)alkyloxycarbonyl, (cycloheteroalkyl)alkyloxycarbonyl, iminoalkyl, iminocycloalkyl, iminocycloheteroalkyl, iminoaralkyl, iminoheteroaralkyl, (cycloalkyl)iminoalkyl, and (cycloheteroalkyl)iminoalkyl

Y is optionally present; and

when Y is present, Y is NR 12 , O, S, SO, or SO 2 , or a single or double bond between X 2 and X 3 ;

R 12 is hydrogen or optionally substituted alkyl, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, cycloalkylcarbonyl, cycloheteroalkylcarbonyl, aralkylcarbonyl, heteroaralkylcarbonyl, (cycloalkyl)alkylcarbonyl, (cycloheteroalkyl)alkylcarbonyl, alkylaminocarbonyl, arylaminocarbonyl, aralkylaminocarbonyl, heteroarylaminocarbonyl, heteroaralkylaminocarbonyl, alkylsulfonyl, arylsulfonyl, heteroarylsufonyl, cycloalkylsulfonyl, alkyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, cycloalkyloxycarbonyl, cycloheteroalkyloxycarbonyl, aralkyloxycarbonyloxycarbonyl, heteroaralkyloxycarbonyl, (cycloalkyl)alkyloxycarbonyl, and (cycloheteroalkyl)alkyloxycarbonyl; and

X 2 and X 3 are (CR 13 R 13′ ) n and (CR 14 R 14′ ) o respectively, wherein each of n and o is independently either 1, 2, or 3 such that the sum n+o is either 3, 4, or 5, and independently for each value of the n and o methylene units of X 2 and X 3 , each of R 13 , R 13′ , R 14 , and R 14′ is selected independently from the group consisting of:

hydrogen, halo, cyano, nitro, thio, amino, carboxy, formyl, and optionally substituted alkyl, alkylcarbonyloxy, arylcarbonyloxy, heteroarylcarbonyloxy, cycloalkylcarbonyloxy, cycloheteroalkylcarbonyloxy, aralkylcarbonyloxy, heteroaralkylcarbonyloxy, (cycloalkyl)alkylcarbonyloxy, (cycloheteroalkyl)alkylcarbonyloxy, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, cycloalkylcarbonyl, cycloheteroalkylcarbonyl, aralkylcarbonyl, heteroaralkylcarbonyl, (cycloalkyl)alkylcarbonyl, (cycloheteroalkyl)alkylcarbonyl, alkylaminocarbonyl, arylaminocarbonyl, aralkylaminocarbonyl, heteroarylaminocarbonyl, heteroaralkylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, cycloalkylcarbonylamino, cycloheteroalkylcarbonylamino, aralkylcarbonylamino, heteroaralkylcarbonylamino, (cycloalkyl)alkylcarbonylamino, (cycloheteroalkyl)alkylcarbonylamino, dialkylamino, arylamino, diarylamino, aralkylamino, diaralkylamino, heteroarylamino, diheteroarylamino, heteroaralkylamino, diheteroaralkylamino, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, cycloalkylsulfonyl, aralkylcarbonylthiooxy, carbonylthio, heteroaralkylcarbonylthio, (cycloalkyloxy)carbonylthio, (cycloheteroalkyl)alkylcarbonylthio, alkyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, cycloalkyloxycarbonyl, cycloheteroalkyloxycarbonyl, aralyoxycarbonyloxloxycarbonyl, heteroaralkyloxycarbonyl, (cycloalkyl)alkyloxycarbonyl, (cycloheteroalkyl)alkyloxycarbonyl, iminoalkyl, iminocycloalkyl, iminocycloheteroalkyl, iminoaralkyl, iminoheteroaralkyl, (cycloalkyl)iminoalkyl, and (cycloheteroalkyl)iminoalkyl; and

when Y is not present X 2 is R 15 and X 3 is R 16 , wherein

R 15 and R 16 are selected independently from the group consisting of: hydrogen and optionally substituted alkyl, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, cycloalkylcarbonyl, cycloheteroalkylcarbonyl, aralkylcarbonyl, heteroaralkylcarbonyl, (cycloalkyl)alkylcarbonyl, (cycloheteroalkyl)alkylcarbonyl, alkylaminocarbonyl, arylaminocarbonyl, aralkylaminocarbonyl, heteroarylaminocarbonyl, heteroaralkylaminocarbonyl, alkylsulfonyl, arylsulfonyl, heteroarylsufonyl, cycloalkylsulfonyl, alkyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, cycloalkyloxycarbonyl, cycloheter-alkyloxycarbonyl, aralkyloxycarbonyloxycarbonyl, heteroaralkyloxycarbonyl, (cycloalkyl)alkyloxycarbonyl, and (cycloheteroalkyl)alkyloxycarbonyl

wherein when said optionally substituted alkyl is substituted, said substitution is with a group which is hydrooxyl, nitro, amino, imino, cyano, halo, thio, thioamido, amidino, oxo, oxamidino, methoxamidino, imidino, guanidino, sulfonamido, carboxyl, formyl, lower alkyl, haloloweralkyl, loweralkoxy, haloloweralkoxy, lower alkoxyalkyl, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, heteroarylcarbonyl, heteroaralkylcarbonyl, alkylthio, aminoalkyl, or cyanoalkyl.

2. A compound of claim 1 , wherein m is 1, such that X 1 is (CR 11′ ), thereby defining X 1 as (CR 11a R 11b ), said compound having the structure:

wherein R 11a and R 11b are selected independently from the group consisting of: hydrogen, halo, cyano, nitro, thio, amino, carboxy, formyl, and optionally substituted alkyl, alkylcarbonyloxy, arylcarbonyloxy, heteroarylcarbonyloxy, cycloalkylcarbonyloxy, cycloheteroalkylcarbonyloxy, aralkylcarbonyloxy, heteroaralkylcarbonyloxy, (cycloalkyl)alkylcarbonyloxy, (cycloheteroalkyl)alkylcarbonyloxy, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, cycloalkylcarbonyl, cycloheteroalkylcarbonyl, aralkylcarbonyl, heteroaralkylcarbonyl, (cycloalkyl)alkylcarbonyl, (cycloheteroalkyl)alkylcarbonyl, alkylaminocarbonyl, arylaminocarbonyl, aralkylaminocarbonyl, heteroarylaminocarbonyl, heteroaralkylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, cycloalkylcarbonylamino, cycloheteroalkylcarbonylamino, aralkylcarbonylamino, heteroaralkylcarbonylamino, (cycloalkyl)alkylcarbonylamino, (cycloheteroalkyl)alkylcarbonylamino, dialkylamino, arylamino, diarylamino, aralkylamino, diaralkylamino, heteroarylamino, diheteroarylamino, heteroaralkylamino, diheteroaralkylamino, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, cycloalkylsulfonyl, aralkylcarbonylthiooxy, carbonylthio, heteroaralkylcarbonylthio, (cycloalkyloxy)carbonylthio, (cycloheteroalkyl)alkylcarbonylthio, alkyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, cycloalkyloxycarbonyl, cycloheteroalkyloxycarbonyl, aralyoxycarbonyloxloxycarbonyl, heteroaralkyloxycarbonyl, (cycloalkyl)alkyloxycarbonyl, (cycloheteroalkyl)alkyloxycarbonyl, iminoalkyl, iminocycloalkyl, iminocycloheteroalkyl, iminoaralkyl, iminoheteroaralkyl, (cycloalkyl)iminoalkyl, and (cycloheteroalkyl)iminoalkyl.

3. A compound of claim 2 , wherein Y is not present, said compound having the structure:

4. A compound of claim 3 , wherein each of R 15 and R 16 is hydrogen.

5. A compound of claim 4 , wherein each of R 2 -R 5 , R 7a -R 9b , R 11a , and R 11b is hydrogen, each of R 1 and R 6 independently is optionally substituted alkyl, and R 10 is optionally substituted alkyl or alkylsulfonyl.

6. A compound of claim 3 , wherein each of R 15 and R 16 independently is alkyl or alkyloxyalkyl.

7. A compound of claim 6 , wherein each of R 15 and R 16 independently is alkyl.

8. A compound of claim 7 , wherein each of R 15 and R 16 independently is methyl or ethyl.

9. A compound of claim 8 , wherein each of R 2 -R 5 , R 7a -R 9b , R 11a , and R 11b is hydrogen, and R 10 is hydrogen, or optionally substituted alkyl, alkyloxycarbonyl, alkylsulfonyl, cycloalkylsulfonyl, and alkylaminosulfonyl.

10. A compound of claim 2 , wherein Y is present, said compound having the structure:

11. A compound of claim 10 , wherein each of n and o is 2, such that X 2 and X 3 have the form (CR 13 R 13′ ) 2 and (CR 14 R 14b ) 2 respectively defining thereby X 2 as (CR 13a R 13b )(CR 13c R 13d ) and X 3 as (CR 14a R 14b ) (CR 14c R 14d ), said compound having the structure:

wherein R 13a -R 14d are selected independently from the group consisting of: hydrogen, halo, cyano, nitro, thio, amino, carboxy, formyl, and optionally substituted alkyl, alkylcarbonyloxy, arylcarbonyloxy, heteroarylcarbonyloxy, cycloalkylcarbonyloxy, cycloheteroalkylcarbonyloxy, aralkylcarbonyloxy, heteroaralkylcarbonyloxy, (cycloalkyl)alkylcarbonyloxy, (cycloheteroalkyl)alkylcarbonyloxy, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, cycloalkylcarbonyl, cycloheteroalkylcarbonyl, aralkylcarbonyl, heteroaralkylcarbonyl, (cycloalkyl)alkylcarbonyl, (cycloheteroalkyl)alkylcarbonyl, alkylaminocarbonyl, arylaminocarbonyl, aralkylaminocarbonyl, heteroarylaminocarbonyl, heteroaralkylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, cycloalkylcarbonylamino, cycloheteroalkylcarbonylamino, aralkylcarbonylamino, heteroaralkylcarbonylamino, (cycloalkyl)alkylcarbonylamino, (cycloheteroalkyl)alkylcarbonylamino, dialkylamino, arylamino, diarylamino, aralkylamino, diaralkylamino, heteroarylamino, diheteroarylamino, heteroaralkylamino, diheteroaralkylamino, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, cycloalkylsulfonyl, aralkylcarbonylthiooxy, carbonylthio, heteroaralkylcarbonylthio, (cycloalkyloxy)carbonylthio, (cycloheteroalkyl)alkylcarbonylthio, alkyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, cycloalkyloxycarbonyl, cycloheteroalkyloxycarbonyl, aralyoxycarbonyloxloxycarbonyl, heteroaralkyloxycarbonyl, (cycloalkyl)alkyloxycarbonyl, (cycloheteroalkyl)alkyloxycarbonyl, iminoalkyl, iminocycloalkyl, iminocycloheteroalkyl, iminoaralkyl, iminoheteroaralkyl, (cycloalkyl)iminoalkyl, and (cycloheteroalkyl)iminoalkyl.

12. A compound of claim 11 , wherein each of R 2 -R 5 , R 7a -R 9b , R 11a , R 11b , and R 13a -R 14d is hydrogen.

13. A compound of claim 12 , wherein Y is NR 12 or O.

14. A compound of claim 13 , wherein Y is NR 12 , and R 10 and R 12 are selected independently from the group consisting of: hydrogen, or optionally substituted alkyl, alkyloxycarbonyl, alkylsulfonyl, cycloalkylsulfonyl, and alkylaminosulfonyl.

15. A compound of claim 13 , wherein Y is O.

16. A compound of claim 1 , wherein m is 2, such that X 1 is (CR 11 R 11′ ) 2 , thereby defining X 1 as (CR 11a R 11b )(CR 11c R 11d ), said compound having the structure:

wherein R 11a -R 11d are selected independently from the group consisting of: hydrogen, halo, cyano, nitro, thio, amino, carboxy, formyl, and optionally substituted alkyl, alkylcarbonyloxy, arylcarbonyloxy, heteroarylcarbonyloxy, cycloalkylcarbonyloxy, cycloheteroalkylcarbonyloxy, aralkylcarbonyloxy, heteroaralkylcarbonyloxy, (cycloalkyl)alkylcarbonyloxy, (cycloheteroalkyl)alkylcarbonyloxy, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, cycloalkylcarbonyl, cycloheteroalkylcarbonyl, aralkylcarbonyl, heteroaralkylcarbonyl, (cycloalkyl)alkylcarbonyl, (cycloheteroalkyl)alkylcarbonyl, alkylaminocarbonyl, arylaminocarbonyl, aralkylaminocarbonyl, heteroarylaminocarbonyl, heteroaralkylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, cycloalkylcarbonylamino, cycloheteroalkylcarbonylamino, aralkylcarbonylamino, heteroaralkylcarbonylamino, (cycloalkyl)alkylcarbonylamino, (cycloheteroalkyl)alkylcarbonylamino, dialkylamino, arylamino, diarylamino, aralkylamino, diaralkylamino, heteroarylamino, diheteroarylamino, heteroaralkylamino, diheteroaralkylamino, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, cycloalkylsulfonyl, aralkylcarbonylthiooxy, carbonylthio, heteroaralkylcarbonylthio, (cycloalkyloxy)carbonylthio, (cycloheteroalkyl)alkylcarbonylthio, alkyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, cycloalkyloxycarbonyl, cycloheteroalkyloxycarbonyl, aralyoxycarbonyloxloxycarbonyl, heteroaralkyloxycarbonyl, (cycloalkyl)alkyloxycarbonyl, (cycloheteroalkyl)alkyloxycarbonyl, iminoalkyl, iminocycloalkyl, iminocycloheteroalkyl, iminoaralkyl, iminoheteroaralkyl, (cycloalkyl)iminoalkyl, and (cycloheteroalkyl)iminoalkyl.

17. A compound of claim 16 , wherein Y is not present, said compound having the structure:

wherein R 11a -R 11d selected independently from the group consisting of: hydrogen, halo, cyano, nitro, thio, amino, carboxy, formyl, and optionally substituted alkyl, alkylcarbonyloxy, arylcarbonyloxy, heteroarylcarbonyloxy, cycloalkylcarbonyloxy, cycloheteroalkylcarbonyloxy, aralkylcarbonyloxy, heteroaralkylcarbonyloxy, (cycloalkyl)alkylcarbonyloxy, (cycloheteroalkyl)alkylcarbonyloxy, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, cycloalkylcarbonyl, cycloheteroalkylcarbonyl, aralkylcarbonyl, heteroaralkylcarbonyl, (cycloalkyl)alkylcarbonyl, (cycloheteroalkyl)alkylcarbonyl, alkylaminocarbonyl, arylaminocarbonyl, aralkylaminocarbonyl, heteroarylaminocarbonyl, heteroaralkylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, cycloalkylcarbonylamino, cycloheteroalkylcarbonylamino, aralkylcarbonylamino, heteroaralkylcarbonylamino, (cycloalkyl)alkylcarbonylamino, (cycloheteroalkyl)alkylcarbonylamino, dialkylamino, arylamino, diarylamino, aralkylamino, diaralkylamino, heteroarylamino, diheteroarylamino, heteroaralkylamino, diheteroaralkylamino, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, cycloalkylsulfonyl, aralkylcarbonylthiooxy, carbonylthio, heteroaralkylcarbonylthio, (cycloalkyloxy)carbonylthio, (cycloheteroalkyl)alkylcarbonylthio, alkyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, cycloalkyloxycarbonyl, cycloheteroalkyloxycarbonyl, aralyoxycarbonyloxloxycarbonyl, heteroaralkyloxycarbonyl, (cycloalkyl)alkyloxycarbonyl, (cycloheteroalkyl)alkyloxycarbonyl, iminoalkyl, iminocycloalkyl, iminocycloheteroalkyl, iminoaralkyl, iminoheteroaralkyl, (cycloalkyl)iminoalkyl, and (cycloheteroalkyl)iminoalkyl.

18. A compound of claim 16 , wherein Y is present, said compound having the structure:

wherein R 11a -R 11d are selected independently from the group consisting of: hydrogen, halo, cyano, nitro, thio, amino, carboxy, formyl, and optionally substituted alkyl, alkylcarbonyloxy, arylcarbonyloxy, heteroarylcarbonyloxy, cycloalkylcarbonyloxy, cycloheteroalkylcarbonyloxy, aralkylcarbonyloxy, heteroaralkylcarbonyloxy, (cycloalkyl)alkylcarbonyloxy, (cycloheteroalkyl)alkylcarbonyloxy, alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, cycloalkylcarbonyl, cycloheteroalkylcarbonyl, aralkylcarbonyl, heteroaralkylcarbonyl, (cycloalkyl)alkylcarbonyl, (cycloheteroalkyl)alkylcarbonyl, alkylaminocarbonyl, arylaminocarbonyl, aralkylaminocarbonyl, heteroarylaminocarbonyl, heteroaralkylaminocarbonyl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, cycloalkylcarbonylamino, cycloheteroalkylcarbonylamino, aralkylcarbonylamino, heteroaralkylcarbonylamino, (cycloalkyl)alkylcarbonylamino, (cycloheteroalkyl)alkylcarbonylamino, dialkylamino, arylamino, diarylamino, aralkylamino, diaralkylamino, heteroarylamino, diheteroarylamino, heteroaralkylamino, diheteroaralkylamino, alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, cycloalkylsulfonyl, aralkylcarbonylthiooxy, carbonylthio, heteroaralkylcarbonylthio, (cycloalkyloxy)carbonylthio, (cycloheteroalkyl)alkylcarbonylthio, alkyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, cycloalkyloxycarbonyl, cycloheteroalkyloxycarbonyl, aralyoxycarbonyloxloxycarbonyl, heteroaralkyloxycarbonyl, (cycloalkyl)alkyloxycarbonyl, (cycloheteroalkyl)alkyloxycarbonyl, iminoalkyl, iminocycloalkyl, iminocycloheteroalkyl, iminoaralkyl, iminoheteroaralkyl, (cycloalkyl)iminoalkyl, and (cycloheteroalkyl)iminoalkyl.

19. A method for treating a viral disease in a mammal afflicted with such disease, comprising administering to such mammal a therapeutically effective amount of the compound of claim 1 wherein said viral disease is influenza, Adenovirus, Human Corona Virus, Herpes Simplex Virus, Rhinovirus, Respiratory Syntactical Virus, Hepatitis C Virus, Human Immunodeficiency Virus, Monkey Pox Virus, Rabies Virus, Dengue Virus, Easter Equine Encephalitis Virus, Venezuelan Equine Encephalitis Virus, Wester Equine Encephalitis Virus, West Nile Virus, Chikungunya Virus, Ebola Virus, or Marburg Virus.

20. The method of claim 19 , wherein said viral disease is an etiological component of a respiratory syndrome selected from the group consisting of: bronchiolitis, the common cold, croup, influenza, and pneumonia.

21. A compound of claim 1 , which is 3-(diethylamino)-1-ethyl-7-(piperazin-1-yl)phenothiazin-5-ium.

22. A compound of claim 1 , which is 3-(1,4-diazepan-1-yl)-7-(dimethylamino)-1,9-diethylphenothiazin-5-ium.

23. A compound of claim 1 , which is 3-(4-(cyclopropylsulfonyl)piperazin-1-yl)-7-(dimethylamino)-1,9-diethylphenothiazin-5-ium.

24. A compound of claim 1 , which is 3,7-di(4-methylpiperazin-1-yl)-1-t-butylphenothiazin-5-ium.

25. A compound of claim 1 , which is 1,9-dichloro-3-(piperazin-1-yl)-7-(pyrrolidin-1-yl)phenothiazin-5-ium.

26. A compound of claim 1 , which is 3,7-(di(4-methylpiperazin-1-yl))-1-ethyl-9-methylphenothiazin-5-ium.

27. A compound of claim 1 , which is 3,7-di(1,4-diazepan-1-yl)-1-ethyl-9-methylphenothiazin-5-ium.

28. A compound of claim 1 , which is 3-(dimethylamino)-1-ethyl-9-methyl-7-(4-(trifluoromethylsulfonyl)piperazin-1-yl)phenothiazin-5-ium.

29. A compound of claim 1 , which is 3,7-di(1,4-diazepan-1-yl)-1-trifluoromethylphenothiazin-5-ium.

30. A compound of claim 1 , which is a member selected from 3-amino-7-(4-isopropylpiperazin-1-yl)-1,9-dimethylphenothiazin-5-ium, 3-amino-1,9-dimethyl-7-(4-(methylsulfonyl)piperazin-1-yl)phenothiazin-5-ium, 3-amino-1,9-dimethyl-7-(4-(trifluoromethylsulfonyl)piperazin-1-yl)phenothiazin-5-ium, and 3-amino-7-(4-(isopropylsulfonyl)piperazin-1-yl)-1,9-dimethylphenothiazin-5-ium.

31. A compound of claim 1 , which is a member selected from 7-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1-chloro-3-(diethylamino)phenothiazin-5-ium, 1-chloro-3-(diethylamino)-7-(piperazin-1-yl)phenothiazin-5-ium, 7-(4-(tert-butoxycarbonyl)piperazin-1-yl)-3-(diethylamino)-1-ethylphenothiazin-5-ium, 3-(diethylamino)-1-ethyl-7-(piperazin-1-yl)phenothiazin-5-ium, 3-(bis(2-methoxyethyl)amino)-7-(4-(tertbutoxycarbonyl)piperazin-1-yl)-1-ethylphenothiazin-5-ium, and 3-(bis(2-methoxyethyl)amino)-1,9-dichloro-7-(piperazin-1-yl)phenothiazin-5-ium.

32. A compound of claim 1 , which is a member selected from 1,9-dichloro-3,7-di(piperazin-1-yl)phenothiazin-5-ium, 1-trifluoromethyl-3,7-di(4-methylpiperazin-1-yl)phenothiazin-5-ium, 3,7-(di(4-Boc-piperazin-1-yl))-1-trifluoromethylphenothiazin-5-ium, 3,7-dipiperazinyl-1-trifluoromethylphenothiazin-5-ium, 3,7-di(4-methylpiperazin-1-yl)-1-n-butylphenothiazin-5-ium, 3,7-di(4-methylpiperazin-1-yl)-1-methylphenothiazin-5-ium, 1-(tert-butyl)-3,7-bis(4-methylpiperazin-1-yl)phenothiazin-5-ium, and 3,7-di(4-methylpiperazin-1-yl)-1-isopropylphenothiazin-5-ium.

33. A compound of claim 1 , which is a member selected from 3-(dimethylamino)-1,9-dimethyl-7-(4-methylpiperazin-1-yl)phenothiazin-5-ium, 3-(4-(tert-butoxycarbonyl)piperazin-1-yl)-7-(dimethylamino)-1,9-dimethylphenothiazin-5-ium, 3-(dimethylamino)-1,9-dimethyl-7-(piperazin-1-yl)phenothiazin-5-ium, 3,7-bis(4-(tert-butoxycarbonyl)piperazin-1-yl)-1,9-dimethylphenothiazin-5-ium, 3-(butyl(methyl)amino)-7-(4-(2-methoxyethyl)piperazin-1-yl)-1,9-dimethylphenothiazin-5-ium, 3-(4-(cyclopropylsulfonyl)piperazin-1-yl)-7-(dimethylamino)-1,9-dimethylphenothiazin-5-ium, 3-(dimethylamino)-7-(4-(isopropylsulfonyl)piperazin-1-yl)-1,9-dimethylphenothiazin-5-ium, 3-(dimethylamino)-1,9-dimethyl-7-(4-(2,2,2-trifluoroethylsulfonyl)piperazin-1-yl)phenothiazin-5-ium, 4-carboxy-3-(dimethylamino)-1,9-dimethyl-7-(4-methylpiperazin-1-yl)phenothiazin-5-ium, 4-carboxy-7-(dimethylamino)-1,9-dimethyl-3-(4-methylpiperazin-1-yl)phenothiazin-5-ium, 3-(4-(cyclopropylsulfonyl)piperazin-1-yl)-7-(dimethylamino)-1-isopropyl-9-methylphenothiazin-5-ium, 3-(diethylamino)-1,9-dimethyl-7-(4-(methylsulfonyl)piperazin-1-yl)phenothiazin-5-ium, 3-(diethylamino)-1,9-dimethyl-7-(piperazin-1-yl)phenothiazin-5-ium, 3-(diethylamino)-7-(4-isopropylpiperazin-1-yl)-1,9-dimethylphenothiazin-5-ium, 3-(diethylamino)-7-(4-isopropylpiperazin-1-yl)-1,9-dimethylphenothiazin-5-ium, 1,9-diethyl-3-dimethylamino-7-[4-isopropylpiperazinyl]-phenothiazinium, 3-(butyl(methyl)amino)-1,9-dimethyl-7-(4-methylpiperazin-1-yl)phenothiazin-5-ium, 3-(dimethylamino)-1,9-diethyl-7-((4-trifluoromethylsulfonyl)piperazin-1-yl)phenothiazin-5-ium, 3-(4-(cyclopentylsulfonyl)piperazin-1-yl)-7-(dimethylamino)-1,9-diethylphenothiazin-5-ium, 3-(dimethylamino)-9-ethyl-1-isopropyl-7-(4-isopropylpiperazin-1-yl)phenothiazin-5-ium, 3-(butyl(methyl)amino)-7-((4-cyclopropylsulfonyl)piperazin-1-yl)-1,9-diethylphenothiazin-5-ium, 3-(4-cyclopentylpiperazin-1-yl)-7-(dimethylamino)-1,9-diethylphenothiazin-5-ium, 3-(dimethylamino)-1,9-diethyl-7-(4-(2-methoxyethyl)piperazin-1-yl)phenothiazin-5-ium, 3-(4-(cyclopropylsulfonyl)piperazin-1-yl)-7-(dimethylamino)-1-ethyl-9-isopropylphenothiazin-5-ium, 3-(dimethylamino)-9-ethyl-1-isopropyl-7-((4-trifluoromethylsulfonyl)piperazin-1-yl)phenothiazin-5-ium, 3-(dimethylamino)-7-(4-(N,N-dimethylsulfamoyl)piperazin-1-yl)-1,9-diethylphenothiazin-5-ium, 3-(4-(cyclopropylsulfonyl)piperazin-1-yl)-7-(dimethylamino)-1,9-diethylphenothiazin-5-ium, 3-((4-tert-butylcarbamoyl)piperazin-1-yl)-7-(dimethylamino)-1,9-diethylphenothiazin-5-ium, 3-(4-butylpiperazin-1-yl)-7-(dimethylamino)-1,9-diethylphenothiazin-5-ium, 3-(4-acetylpiperazin-1-yl)-7-(methyl(n-butyl)amino)-1,9-dimethylphenothiazin-5-ium, 3-(4-boc-piperazin-1-yl)-7-(methyl(n-butyl)amino)-1,9-dimethylphenothiazin-5-ium, 3-(piperazin-1-yl)-7-(methyl(n-butyl)amino)-1,9-dimethylphenothiazin-5-ium, 3-(dimethylamino)-1-ethyl-9-methyl-7-(4-methylpiperazin-1-yl)-phenothiazin-5-ium, 3-(dimethylamino)-1-ethyl-9-methyl-7-(4-(trifluoromethylsulfonyl)piperazin-1-yl)phenothiazin-5-ium, 3-(4-(cyclopropylsulfonyl)piperazin-1-yl)-7-(dimethylamino)-9-ethyl-1-methyl-phenothiazin-5-ium, and 3-(bis(2-methoxyethyl)amino)-1-ethyl-9-methyl-7-(4-methylpiperazin-1-yl)phenothiazin-5-ium.

34. A compound of claim 1 , which is a member selected from 1,9-dimethyl-3,7-bis(4-methylpiperazin-1-yl)phenothiazin-5-ium, 3,7-bis(4-(tert-butoxycarbonyl)piperazin-1-yl)-1,9-dimethylphenothiazin-5-ium, 3,7-bis[4-(2-methoxyethyl)piperazin-1-yl]-1,9-dimethyl-phenothiazin-5-ium, 1,9-dimethyl-3,7-bis(4-sulfamoylpiperazin-1-yl)phenothiazin-5-ium, 3,7-bis(4-isopropylpiperazin-1-yl)-1,9-dimethylphenothiazin-5-ium, 3, 7 bis(4(cyclopropanecarbonyl)piperazin-1-yl)-1,9-diethylphenothiazin-5-ium, 3,7-bis(4-(cyclopropylsulfonyl)piperazin-1-yl)-1,9-diethyl-phenothiazin-5-ium, 3,7-di(4-acetylpiperazin-1-yl)-1,9-dimethylphenothiazin-5-ium, and 3,7-(di(4-methylpiperazin-1-yl))-1-ethyl-9-methylphenothiazin-5-ium.

35. A compound of claim 1 , which is a member selected from 1,9-dimethyl-3-morpholino-7-(4-sulfamoylpiperazin-1-yl)phenothiazin-5-ium, 3-((2R,6S)-2,6-dimethylmorpholino)-1,9-dimethyl-7-(4-sulfamoylpiperazin-1-yl)phenothiazin-5-ium, 3-((2R,6R)-2,6-dimethylmorpholino)-1,9-dimethyl-7-(4-sulfamoylpiperazin-1-yl)phenothiazin-5-ium, 1,9-diethyl-3-morpholino-7-(4-sulfamoylpiperazin-1-yl)phenothiazin-5-ium, 3-(4-(tert-butoxycarbonyl)-3-(methoxycarbonyl)-piperazin-1-yl)-1,9-diethyl-7-morpholinophenothiazin-5-ium, 3-(4-boc-piperazin-1-yl)-1-ethyl-9-methyl-7-morpholino-phenothiazin-5-ium, and 1-ethyl-9-methyl-7-morpholino-3-(piperazin-1-yl)-phenothiazin-5-ium.

36. A compound of claim 1 , which is a member selected from 3-(azetidin-1-yl)-7-(4-(isopropylsulfonyl)piperazin-1-yl)-1,9-dimethylphenothiazin-5-ium, 1,9-dimethyl-3-(pyrrolidin-1-yl)-7-(4-(2,2,2-trifluoroethylsulfonyl)piperazin-1-yl)phenothiazin-5-ium, and 3-(4-(cyclopropylsulfonyl)piperazin-1-yl)-9-ethyl-1-methyl-7-(pyrrolidin-1-yl)-phenothiazin-5-ium.

37. A compound of claim 1 , which is a member selected from 3-(4-(cyclopropylsulfonyl)-1,4-diazepan-1-yl)-7-(dimethylamino)-1,9-diethylphenothiazin-5-ium, 3-(dimethylamino)-1,9-diethyl-7-((methylsulfonyl)-1,4-diazepan-1-yl)phenothiazin-5-ium, 3-(dimethylamino)-1,9-diethyl-7-(4-(ethylsulfonyl)-1,4-diazepan-1-yl)phenothiazin-5-ium, 3-(4-(tert-butylcarbamoyl)-1,4-′diazepan-1-yl)-7-(dimethylamino)-1,9-diethylphenothiazin-5-ium, 3-(dimethylamino)-1,9-diethyl-7-(4-sulfamoyl-1,4-diazepan-1-yl)phenothiazin-5-ium, 3-(dimethylamino)-1,9-diethyl-7-(4-(isopropylsulfonyl)-1,4-diazepan-1-yl)phenothiazin-5-ium, 3-(dimethylamino)-1,9-diethyl-7-(4-(methylbut-2-enyl)-1,4-diazepan-1-yl)phenothiazin-5-ium, 3-(4-(tert-butoxycarbonyl)-1,4-diazepan-1-yl)-7-(dimethylamino)-1,9-diethylphenothiazin-5-ium, and 3-(1,4-diazepan-1-yl)-7-(dimethylamino)-1,9-diethylphenothiazin-5-ium.

38. A compound of claim 1 , which is a member selected from 3,7-di(1,4-diazepan-1-yl)-1,9-dimethylphenothiazin-5-ium, 3-(1,4-diazepan-1-yl)-1,9-diethyl-7-(4-ureidopiperidin-1-yl)phenothiazin-5-ium, 3,7-di(1,4-diazepan-1-yl)-1,9-diethylphenothiazin-5-ium, 3-(4-(tert-butoxycarbonyl)-1,4-diazepan-1-yl)-1,9-diethyl-7-(2-methylpyrrolidin-1-yl)phenothiazin-5-ium, 3-(1,4-diazepan-1-yl)-1,9-diethyl-7-(2-methylpyrrolidin-1-yl)phenothiazin-5-ium, 3,7-bis(4-(tert-butoxycarbonyl)-1,4-diazepan-1-yl)-1,9-diethylphenothiazin-5-ium, 1-ethyl-9-methyl-7-((4-m ethylsulfonyl)-1,4-diazepan-1-yl)-3-(pyrrolidin-1-yl)-phenothiazin-5-ium, 3,7-bis(4-boc-1,4-diazepan-1-yl)-1-ethyl-9-methyl-phenothiazin-5-ium, 3-(4-boc-1,4-diazepan-1-yl)-1-ethyl-9-methyl-7-(pyrrolidin-1-yl)-phenothiazin-5-ium, 3,7-di(1,4-diazepan-1-yl)-1-ethyl-9-methyl-phenothiazin-5-ium, and 3-(1,4-diazepan-1-yl)-1-ethyl-9-methyl-7-(pyrrolidin-1-yl)-phenothiazin-5-ium.

39. The method of claim 19 , wherein said viral disease is influenza.

40. The method of claim 19 , wherein said viral disease is Human Immunodeficiency Virus.

41. A compound of claim 1 , which is 7-(4-methylpiperazin-1-yl)-3-(pyrrolidin-1-yl)-1-(trifluoromethyl)phenothiazin-5-ium.