IP Library › Granted Patent US 8,877,188
Granted Patent B2
US 8,877,188 · App. 13/100,528 · Granted Nov 4, 2014

Detection and treatment of non-dermal fibrosis

Inventors: Sandeep K. Agarwal (Houston, TX); Michael B. Brenner (Newton, MA)
Assignees: The Brigham and Women's Hospital, Inc.; Board of Regents, The University of Texas System
A61K31/00A61K2039/505C12Q1/6883G01N2333/705C12Q2600/158A61K31/713A61K45/06A61K39/395G01N2800/12G01N33/6884C07K16/28
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Quick Facts
Patent No.
US 8,877,188
App. No.
13/100,528
Granted
Nov 4, 2014
Kind
B2
Abstract

The invention relates to methods for the diagnosis, prognosis, and treatment of non-dermal fibrosis, including lung (or pulmonary) fibrosis.

Claims (8)

1. A method for treating a subject having lung fibrosis comprising

administering to a subject in need thereof an anti-cadherin-11 antibody or an antigen-binding fragment thereof in an amount effective to reduce lung fibrosis.

2. The method of claim 1 , wherein lung fibrosis is idiopathic pulmonary fibrosis.

3. The method of claim 2 , wherein idiopathic pulmonary fibrosis is severe idiopathic pulmonary fibrosis.

4. The method of claim 1 , wherein the anti-cadherin-11 antibody or the antigen-binding fragment thereof is administered by inhalation or intranasally.

5. The method of claim 1 , wherein the anti-cadherin-11 antibody or the antigen-binding fragment thereof is administered intraperitoneally.

6. The method of claim 1 , further comprising administering to the subject an immunosuppressant.

7. The method of claim 6 , wherein the immunosuppressant is a steroid.

Assignments (5)
CONFIRMATORY LICENSE Recorded Dec 22, 2011
From: BRIGHAM & WOMEN'S HOSPITAL, INC.
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 027437/0865 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE NAME PREVIOUSLY RECORDED ON REEL 026456 FRAME 0934. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNEE NAME FOR THE BRIGHAM AND WOMEN'S HOSPITAL, INC. WAS SPELLED INCORRECTLY. Recorded Aug 23, 2011
From: AGARWAL, SANDEEP K.
To: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 026790/0236 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 8, 2011
From: SCHNEIDER, DANIEL J.
To: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 026560/0117 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 15, 2011
From: AGARWAL, SANDEEP K.
To: THE BRIGHAM AND WOMEN'S HOPSITAL, INC.; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 026456/0934 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 31, 2011
From: BRENNER, MICHAEL B.
To: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Reel/Frame 026364/0759 →
Continuity (2)
Provisional Application 61331355 · May 4, 2010
Related Publication 20110274703A1 · Nov 10, 2011