Granted Patent
B2
US 9,453,005 · App. 13/119,052 · Granted Sep 27, 2016
Inhibition of influenza M2 proton channel
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Abstract
Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
Claims (2)
1. A method of treating an infection by influenza A virus comprising the step of administering to a subject in need thereof a composition comprising any of compounds 2-7, 10-12, and 14-27:
or a stereoisomer, partial stereoisomer, pharmaceutically acceptable salt, or N-oxide thereof.
Assignments (2)
CONFIRMATORY LICENSE
Recorded Dec 7, 2017
From: UNIVERSITY OF PENNSYLVANIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 044749/0357 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 13, 2011
From: DEGRADO, WILLIAM F.; WANG, JUN
To: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Reel/Frame 026114/0190 →
Continuity (2)
Provisional Application
61097474
· Sep 16, 2008