METHOD FOR PRODUCING ACRYLAMIDE
[Problem] The present invention provides a method for producing acrylamide from acrylonitrile using a biocatalyst with high productivity at low cost, in which reaction heat can be efficiently removed even at an industrial reaction scale. [Means for Solving] The present invention relates to a method for producing acrylamide by reacting acrylonitrile in the presence of a biocatalyst, wherein the reaction is performed using a reactor having a reaction volume of 1 m 3 or more equipped with a tubular heat exchanger, and wherein the difference between a temperature of a cooling water to be introduced into the heat exchanger and a reaction temperature is maintained from 5 to 20° C.
1 . A method for producing acrylamide by reacting acrylonitrile in the presence of a biocatalyst, wherein the reaction is performed using a reactor having a reaction volume of 1 m 3 or more equipped with a tubular heat exchanger, and wherein the difference between a temperature of a cooling water to be introduced into the heat exchanger and a reaction temperature is maintained from 5 to 20° C.
2 . The method according to claim 1 , wherein the reaction is a continuous reaction.
3 . The method according to claim 2 , wherein the reaction is performed with a value that is obtained by dividing the difference between an acrylamide concentration in a reaction mixture at an inlet of the reactor and that at an outlet of the reactor (wt %) by the difference between the temperature of the cooling water and the reaction temperature (° C.) being maintained within a range of 1.5 to 2.5.
4 . The method according to claim 1 , wherein the tubular heat exchanger is a double or more coil type heat exchanger.
5 . The method according to claim 1 , wherein the tubular heat exchanger is a multitubular heat exchanger.
6 . The method according to claim 5 , wherein the multitubular heat exchanger is a U-tube type heat exchanger.
7 . The method according to claim 6 , wherein the number of flow paths of the U-tube type heat exchanger is 2 to 6.
8 . The method according to claim 6 , wherein the U-tube type heat exchanger is installed upright in the reactor.
9 . The method according to claim 6 , wherein the U-tube type heat exchanger has a structure in which a tube bundle thereof is detachable.