Long-chain carboxychromanols and analogs for use as anti-inflammatory agents
Provided are long-chain carboxychromanol compounds useful for treating conditions associated with the need to inhibit cyclooxygenase-1, cyclooxygenase-2, and/or 5-lipoxygenase, and pharmaceutical formulations containing the compounds.
1. A method for treating a physiological disorder associated with an excess of cyclooxygenase-1 or cyclooxygenase-2, wherein said disorder is cancer, comprising administering a therapeutic amount of compound of the formula
or a pharmaceutically acceptable salt thereof, to a patient in need thereof.
2. The method of claim 1 wherein said patient is a human.
3. The method of claim 1 wherein said patient is additionally administered sesamin or a pharmaceutically acceptable polyphenolic sulfation inhibitor.
4. The method of claim 3 wherein said polyphenolic sulfation inhibitor is circumin.
5. A method for treating a physiological disorder associated with an excess of 5-lipoxygenase, wherein said disorder is cancer, comprising administering a therapeutic amount of a compound of the formula
a pharmaceutically acceptable salt thereof, to a patient in need thereof.
6. The method of claim 5 wherein said patient is a human.
7. The method of claim 5 wherein said patient is additionally administered sesamin or a pharmaceutically acceptable polyphenolic sulfation inhibitor.
8. The method of claim 7 wherein said polyphenolic sulfation inhibitor is circumin.