Fused ring heteroaryl kinase inhibitors
View Patent ↗Provided herein are fused ring heteroaryl compounds useful in a variety of methods, including reducing the activity of certain kinases and treating certain disease states.
1. A compound having the formula:
wherein
x is an integer from 0 to 4;
y is an integer from 0 to 5;
ring A is arylene or heteroarylene;
ring B is aryl or heteroaryl;
Z 1 is —N═ or —C(R 22 )═;
Z 2 is —N═ or —C(R 23 )═;
R 1 and R 2 are independently hydrogen, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl;
R 3 is independently —CN, —CF 3 , —S(O) n R 6 , —N(O) m , —NR 7 R 8 , —C(O)R 9 , —NR 10 —C(O)R 11 , —NR 12 —C(O)—OR 13 , —C(O)NR 14 R 15 , —NR 16 S(O) 2 R 17 , —S(O) 2 NR 18 R 18′ , —OR 19 , halomethyl, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
R 22 and R 23 are independently —CN, —CF 3 , —S(O) n R 6 , —N(O) m , —NR 7 R 8 , —C(O)R 9 , —NR 10 —C(O)R 11 , —NR 12 —C(O)—OR 13 , —C(O)NR 14 R 15 , —NR 16 S(O) 2 R 17 , —S(O) 2 NR 18 R 18′ , —OR 19 , halomethyl, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
R 4 and R 5 are independently halogen, —CN, —CF 3 , —S(O) n R 6 , —N(O) m , —NR 7 R 8 , —C(O)R 9 , —NR 10 —C(O)R 11 , —NR 12 —C(O)—OR 13 , —C(O)NR 14 R 15 , —NR 16 S(O) 2 R 17 , —S(O) 2 NR 18 R 18′ , —OR 19 , halomethyl, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
n is an integer from 0 to 2;
m is an integer from 1 to 2;
R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 , R 16 , R 17 , R 18 , R 18′ , and R 19 are independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
L 1 is a bond, substituted or unsubstituted alkylene or substituted or unsubstituted heteroalkylene;
L 2 is —C(O)—;
L 3 is —NH—; and
L 4 is —NH—.
2. The compound of claim 1 , wherein ring A is phenylene, and ring B is phenyl.
3. The compound of claim 1 , wherein R 1 and R 2 are hydrogen.
4. The compound of claim 1 , wherein R 3 is unsubstituted alkyl.
5. The compound of claim 1 , wherein R 3 is methyl, ethyl or isopropyl.
6. The compound of claim 1 , wherein R 5 is —CF 3 .
7. The compound of claim 1 having the formula:
8. The compound of claim 7 , wherein
R 1 and R 2 are hydrogen;
R 3 is methyl, ethyl, or isopropyl;
R 5 is independently —CF 3 or halogen;
R 20 is hydrogen;
L 1 is a bond or methylene;
L 3 is —N(R 20 )—; and
y is 1 or 2.
9. A compound of claim 1 having the formula
10. The compound of claim 1 , wherein L 1 is a bond.