Tropane urea derivatives, preparation thereof and therapeutic application thereof as modulators of the activity of 11betaHSD1

1. A compound corresponding to formula (I)

in which

A is a bond or an —O—(CH 2 ) n — group with n being a number equal to 0 or 1,

D is a bond or an oxygen atom,

G is a carbon or nitrogen atom,

Ar1 is an aryl or heteroaryl group,

Ar2 is an aryl or heteroaryl or heterocycloalkyl group,

R1 is a hydrogen atom, or a (C1-C6)alkyl, —SO 2 —(C1-C6)alkyl, —SO 2 -halo(C1-C6)alkyl, (C1-C6)alkoxy or —Si(alkyl) 3 group,

R2 is a hydrogen atom or a hydroxyl group or, when G is a nitrogen atom, R2 is absent,

R3 is a hydroxyl or —C(O)-NH 2 group,

in the form of a base or of an addition salt with an acid.

2. A compound of formula (I) as claimed in claim 1 , wherein the substituents of the Ar1 group are in the para-position with respect to one another.

3. A compound of formula (I) as claimed in claim 1 , wherein the substituents of the Ar2 group are in the para-position with respect to one another.

4. A compound of formula (I) as claimed in claim 1 , wherein G is a carbon atom.

5. A compound of formula (I) as claimed in claim 1 , wherein G is a nitrogen atom.

6. A compound of formula (I) as claimed in claim 1 , wherein R3 is —C(O)—NH 2 .

7. A process for preparing a compound of formula (I) as claimed in claim 1 , wherein a compound of formula (IV):

in which A, D, G, Ar1, Ar2, R1 and R2 are as defined in claim 1 and Lg is a leaving group, is reacted with a compound of formula (V):

in which R3 is as defined in claim 1 ,

in the presence of a solvent and of a base.

8. A pharmaceutical composition, comprising the compound of formula (I) as claimed in claim 1 or a pharmaceutically acceptable salt, and at least one pharmaceutically acceptable excipient.

9. The A method of treating obesity, diabetes, insulin resistance, metabolic syndrome, Cushing's syndrome, hypertension, atherosclerosis, cognition and dementia, glaucoma, and osteoporosis by increasing the effectiveness of the immune system in a patient in need thereof comprising administering to said patient a therapeutically effecti ve amount of the pharmaceutical composition of claim 8 .