Polyesters with grafted zwitterions
The invention relates to polymers, such as aliphatic polyesters, with grafted zwitterions. More particularly, the invention relates to polyester-graft-phosphorylcholine polymers prepared by ring-opening polymerization and click chemistry, compositions and products comprising same, and related methods and uses, for example, in drug delivery.
1. A polymer network comprising the following monomer subunits:
and further comprising at least one of the following monomer subunits:
wherein
R 1 is a group comprising a zwitterionic moiety selected from sulfobetaine and phosphorylcholine;
R 2 , R 3 , R 4 , R 5 , R 6 each is independently selected from the group consisting of hydrogen and (C 1 -C 15 ) alkyl;
a each is 0, 1, 2, or 3;
b each is, 1, 2, 3, 4, 5, or 6;
A is selected from camptothecin, irinotecin, SN-38, and derivatives thereof; and
each of L 1 ′, L 2 ′ and L 3 ′ is independently a linker group linked to A or R 1 , wherein at least one of L 1 ′, L 2 ′ and L 3 ′ comprises
wherein the polymer network is crosslinked.
2. The polymer network of claim 1 , wherein the ratio of zwitterionic moiety : A is from about 2 : 1 to about 10 : 1.
3. The polymer of claim 2 , wherein the polymer has a M w from about 8 kDa to about 100 kDa and a M n from about 5 kDa to about 80 kDa.
4. The polymer network of claim 1 , wherein the ratios of (I) : (II) : (III) is about (10%-60%) : (10%-60%) : (5%-40%).
5. The polymer network of claim 1 , wherein each of R 2 , R 3 , R 4 , R 5 , and R 6 is independently selected from the group consisting of hydrogen, methyl and ethyl.
6. The polymer network of claim 1 , wherein the sulfobetaine has the structure:
wherein n is an integer from about 1 to about 15.