Drug composition cytotoxic for pancreatic cancer cells
View Patent ↗Disclosed herein are compositions comprising a drug combination that comprises ZD and S3I-201, Das and S3I-201, ZD and AG490, or Das and AG490. The disclosed drug combinations target two or more functional elements such as EGFR or Src and Stat3 or Jaks in pancreatic cancer cells. Also disclosed herein are methods of using the disclosed compositions to cytotoxically affect pancreatic cancer cells and methods of making the disclosed compositions.
1. A pharmaceutical composition comprising:
a drug combination selected from gefitinib (ZD-1839 or ZD) and 74859 (S3I-201), Das and S3I-201, ZD and tyrphostin AG 490 (AG490), and dasatinib (Das) and AG490 in a pharmaceutically acceptable carrier.
2. The cytotoxic pharmaceutical composition of claim 1 , further comprising gemcitabine.
3. A method of cytotoxically affecting pancreatic cancer cells in a host in need thereof, comprising:
contacting said pancreatic cells with a pharmaceutical composition comprising a drug combination that targets two or more cellular functional elements in pancreatic cancer cells selected from ZD and S3I-201, Das and S3I-201, ZD and AG490, and Das and AG490.
4. The method of claim 3 , wherein two or more functional elements in pancreatic cancer cells comprise one of EGFR or Src and one of Stat3 or Jaks.
5. The method of claim 3 , wherein the pharmaceutical composition further comprises gemcitabine.
6. The method of claim 3 ,
wherein the drug combination is ZD and S31-201 and the two or more functional elements in pancreatic cancer cells comprise EGFR and Stat3,
wherein the drug combination is Das and S31-201 and the two or more functional elements in pancreatic cells comprise Src and Stat3;
wherein the drug combination is ZD and AG490 and the two or more functional elements in pancreatic cancer cells comprise EGFR and Jaks, or
wherein the drug combination is Das and AG490 and the two or more functional elements in pancreatic cancer cells comprise Src and Jaks.
7. The method of claim 3 , wherein the administration of a pharmaceutical composition suppresses c-myc expression in pancreatic cancer cells.
8. The method of claim 3 , wherein the pharmaceutical composition further comprises a pharmaceutically acceptable carrier.
9. A method of making a pharmaceutical composition, comprising:
mixing a pharmaceutically acceptable carrier and a drug combination selected from ZD and S3I-201, Das and S3I-201, ZD and AG490, and Das and AG490.
10. The method of claim 9 , wherein the pharmaceutical composition further comprises gemcitabine.