Compositions and methods for treatment or prevention of
Compositions and methods for treating or preventing S. aureus infections are provided. The compositions can be formulated as pharmaceutical compositions or as disinfectants, sanitizers, detergents or antiseptics, and can be used to eradicate or reduce S. aureus populations and thereby treat or prevent infection by S. aureus . The compositions include one or more digestive enzymes, e.g., one or more protease, lipases, and amylases. Methods of use of the compositions are also provided.
1. A method for the treatment or prevention of Staphylococcus aureus infection in a bird or a mammal, comprising administering to the bird or mammal a therapeutically effective amount of an oral pharmaceutical composition comprising digestive enzymes and a pharmaceutically acceptable excipient, wherein the digestive enzymes comprise a protease, an amylase, and a lipase, wherein the pharmaceutical composition is bacteriocidal or bacteriostatic for Staphylococcus aureus , wherein the pharmaceutical composition is formulated for oral administration, and wherein a ratio of total protease to total lipase ranges from about 1:1 to about 20:1.
2. The method of claim 1 , wherein the digestive enzymes comprise pancreatic enzymes.
3. The method of claim 1 , wherein the digestive enzymes comprise pig enzymes.
4. The method of claim 1 , wherein the protease comprises chymotrypsin and trypsin.
5. The method of claim 1 , wherein the digestive enzymes are, independently, derived from an animal source, a microbial source, a plant source, or a fungal source, or are synthetically prepared.
6. The method of claim 1 , wherein the mammal is a pig, horse, cow, dog, cat, monkey, rat, mouse, sheep, goat, or human, and wherein the bird is a chicken, duck, turkey, or goose.
7. The method of claim 5 , where the animal source is a pig pancreas.
8. The method of claim 1 , wherein the ratio of total protease to total lipase ranges from about 4:1 to about 10:1.
9. The method of claim 1 , wherein the pharmaceutical composition is a dosage formulation selected from the group consisting of: pills, tablets, capsules, caplets, sprinkles, emulsions, powders, liquids, gels, and a combination of any thereof.
10. The method of claim 1 , further comprising administering a beta-lactam antibiotic to the bird or mammal.
11. The method of claim 1 , wherein the ratio of total protease to total lipase is about 4:1.
12. The method of claim 1 , wherein the ratio of total protease to total lipase is about 5:1.
13. The method of claim 1 , wherein the ratio of total protease to total lipase is about 7:1.
14. The method of claim 1 , wherein the ratio of total protease to total lipase is about 10:1.
15. The method of claim 1 , wherein the ratio of total protease to total lipase is about 12:1.
16. The method of claim 1 , wherein the pharmaceutical composition comprises about 200 USP units/mg of protease, about 40 USP units/mg of lipase, and about 250 USP units/mg of amylase.