IP Library Patent Application 13148769
Patent Application
App. No. 13/148,769

PARTICULATE COMPOSITION AND THE METHOD OF MAKING THE SAME

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Quick Facts
Patent No.
US None
App. No.
13/148,769
Abstract

A particulate material for delivering an active ingredient and a method for making the same is provided. The particulate material can be included in a solid dosage form to provide both high tablet strength and smooth-dissolving mouth-feel. The particulate material includes at least two low moldability sugars, such as, dextrose and sucrose, in an amount of from about 70% to about 100% of the particulate material and is granulated in the presence of a binding agent.

Claims (41)

1 . A particulate material for delivering an active ingredient comprising:

at least two low-moldability sugars in an amount of from about 70% to about 100% of the particulate material, and granulated in the presence of a binding agent and having a mean particle size of from 50 to 500 microns.

2 . The particulate material according to claim 1 wherein the at least two low-moldability sugars are dextrose and sucrose.

3 . The particulate material according to claim 2 wherein the dextrose and sucrose are present in a ratio of 85:15 to 15:85.

4 . The particulate material according to claim 3 wherein the dextrose and sucrose are present in a ratio of 70:30 to 50:50.

5 . The particulate material according to claim 1 wherein the mean particle size is 100 to 300 microns.

6 . The particulate material according to claim 1 wherein the binding agent comprises solubilizied dextrose.

7 . The particulate material according to claim 1 wherein the binding agent comprises solubilizied dextrose and maltodextrin.

8 . The particulate material according to claim 1 further comprising up to about 30% of an additive selected from the group consisting of maltodextrin, microcrystalline cellulose, starch, and sugar alcohols.

9 . A solid dosage form for delivering an active ingredient comprising:

a particulate material having at least two low-moldability sugars in an amount of from about 70% to about 100% of the particulate material, and granulated in the presence of a binding agent and said particulate material having a mean particle size of from 50 to 500 microns and an active ingredient.

10 . The solid dosage form according to claim 9 wherein said at least two low-moldability sugars are dextrose and sucrose.

11 . The solid dosage form according to claim 10 wherein said dextrose and sucrose are present in a ratio of about 85:15 to about 15:85 in said particulate material.

12 . The solid dosage form according to claim 11 wherein said dextrose and sucrose are present in a ratio of about 70:30 to 50:50 in said particulate material.

13 . The solid dosage form according to claim 9 , wherein said particulate material and said active ingredient are present in a ratio of about 99:1 to about 1:99.

14 . The solid dosage form according to claim 13 , wherein said particulate material and said active ingredient are present in a ratio of about 9:1 to about 1:9.

15 . The solid dosage form according to claim 13 , wherein said particulate material and said active ingredient are present in a ratio of about 9:1 to about 2:1.

16 . The solid dosage form according to claim 9 wherein said binding agent comprises solubilized dextrose.

17 . The solid dosage form according to claim 16 wherein the binding agent further comprises maltodextrin.

18 . The solid dosage form according to claim 9 wherein the mean particle size is 100 to 300 microns.

19 . The solid dosage form according to claim 9 wherein the active ingredient is selected from the group consisting of pharmaceuticals, vitamins, minerals, herbs, enzymes, nutritional supplements and combinations thereof.

20 . The solid dosage form according to claim 9 wherein the active ingredient is selected from the group consisting of caffeine, acetaminophen, ibuprofen, aspirin, and multivitamins.

21 . The solid dosage form according to claim 9 wherein the active ingredient is microencapsulated.

22 . The solid dosage form according to claim 9 , selected from the group consisting of a directly compressed tablet and a directly compressed caplet.

23 . The solid dosage form according to claim 9 selected from the group consisting of a chewable tablet, a chewable caplet, a rapid dissolve tablet, a rapid dissolve caplet, an orally disintegrating tablet, and an orally disintegrating caplet.

24 . The solid dosage form according to claim 9 is powder dosage form.

25 . The solid dosage form according to claim 24 , wherein the powder dosage form is selected from the group consisting of a sachet and a stick pack.

26 . The solid dosage form according to claim 9 wherein the particulate material and active ingredient together comprise at least 90% of the solid dosage form.

27 . The solid dosage form according to claim 26 wherein the particulate material and active ingredient together comprise at least 70% of the solid dosage form.

28 . The solid dosage form according to claim 9 wherein the particulate material and active ingredient together comprise at least 50% of the solid dosage form.

29 . A method of forming a particulate material comprising:

granulating at least two low-moldability sugars in an amount of from about 70% to about 100% of the particulate material in the presence of a binding agent to form a particulate material and drying said particulate material to a low moisture content.

30 . The method according to claim 29 wherein said at least two low-moldability sugars are dextrose and sucrose.

31 . The method according to claim 30 wherein said dextrose and sucrose are present in the particulate material in a ratio of 85:15 to 15:85.

32 . The method according to claim 31 wherein said dextrose and sucrose are present in the particulate material in a ratio of 70:30 to 50:50.

33 . The method according to claim 29 wherein the binding agent comprises solubilized dextrose.

34 . The method according to claim 33 wherein the binding agent further comprises maltodextrin.

35 . The method according to claim 29 wherein said low moisture content is not more than 10% loss on drying.

36 . The method according to claim 35 wherein said low moisture content is not more than 7% loss on drying.

37 . The method according to claim 29 wherein said granulating is a wet granulation process.

38 . The method according to claim 37 wherein said wet granulation process is a fluid bed granulation.

Assignments (3)
TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENTS Recorded Jun 29, 2018
From: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT
To: BALCHEM CORPORATION
Reel/Frame 046464/0737 →
NOTICE OF GRANT OF SECURITY INTEREST IN PATENTS Recorded May 8, 2014
From: BALCHEM CORPORATION
To: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 032854/0635 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 28, 2011
From: YU, LIANGPING; BAKER, CARL; DESISTO, DOUG, SR.; RICHARDSON, PAUL
To: BALCHEM CORPORATION
Reel/Frame 027139/0273 →