Medical tape preparation
A medical tape preparation which comprises a support and, superposed on one side thereof in the following order, a pressure-sensitive adhesive layer and a release liner. The pressure-sensitive adhesive layer can contain a large amount of an oleophilic oily matter. The tape preparation is excellent in adhesion, cohesiveness, and stability even when no crosslinking agent is used. The pressure-sensitive adhesive layer in the medical tape preparation comprises a blend of two tacky polymers, which are a tacky polymer (A) comprising a copolymer obtained from 2-acetoacetoxyethyl methacrylate and other vinyl monomer(s) as constituent ingredients and a tacky polymer (B) comprising a copolymer which is obtained from a C 4-10 -alkyl(meth)acrylate and other vinyl monomer(s) as constituent ingredients and is different from the tacky polymer (A).
1. A medical tape preparation comprising a pressure-sensitive adhesive layer and a release liner laminated in that order on one side of a support, wherein the pressure-sensitive adhesive layer comprises a pressure-sensitive adhesive that is a mixture of two different pressure-sensitive adhesives:
(A) a pressure-sensitive adhesive polymer A comprising a copolymer whose constituent components comprise 2-acetoacetoxyethyl methacrylate ester and another vinyl monomer, and
(B) a pressure-sensitive adhesive polymer B comprising a copolymer different from pressure-sensitive adhesive polymer A, whose constituent components comprise an alkyl (meth)acrylate ester with a C 4-10 alkyl group and another vinyl monomer,
wherein the proportion of the pressure-sensitive adhesive polymer A and the pressure-sensitive adhesive polymer B is 1:9-4:1,
and the content of the 2-acetoacetoxyethyl methacrylate ester in pressure-sensitive adhesive polymer A is 10 wt %-45 wt % with respect to the total weight of the copolymer in pressure-sensitive adhesive polymer A.
2. The medical tape preparation according to claim 1 , wherein:
(A) the pressure-sensitive adhesive polymer A comprises 2-acetoacetoxyethyl methacrylate ester, and one or more vinyl monomer selected from:
alkyl(meth)acrylate esters with C 4-10 alkyl groups,
methyl methacrylate,
diacetoneacrylamide,
tetraethyleneglycol di(meth)acrylate,
hexaethyleneglycol di(meth)acrylate, and
2-hydroxyethyl(meth)acrylate ester,
and
(B) the pressure-sensitive adhesive polymer B comprises alkyl(meth)acrylate ester with a C 4-10 alkyl group and one or more vinyl monomer selected from:
methyl methacrylate,
diacetoneacrylamide,
2-hydroxyethyl(meth)acrylate ester,
N-vinyl-2-pyrrolidone, and
vinyl acetate.
3. A medical tape preparation according to claim 1 , wherein said pressure-sensitive adhesive layer further comprising a plasticizer comprising an oil component that is compatible with the pressure-sensitive adhesive composed of the mixture of the pressure-sensitive adhesive polymer A as component (A) and the pressure-sensitive adhesive polymer B as component (B).
4. A medical tape preparation according to claim 3 , wherein said plasticizer is one or more oils selected from the group consisting of isopropyl myristate, diethyl sebacate, diisopropyl adipate, medium chain fatty acid triglyceride and castor oil.
5. A medical tape preparation according to claim 1 , wherein the pressure-sensitive adhesive layer contains a percutaneous absorbable drug.