Metabolites of wortmannin analogs and methods of using the same
View Patent ↗Novel metabolites of wortmannin and wortmannin analogs and their use in inhibiting PI-3 kinase activity in mammals and the treatment and prevention of cancer or tumor formation in a subject are described herein.
1. A pharmaceutical composition comprising 17-hydroxy wortmannin compound having the structure:
wherein:
R 1 and R 2 are independently unsaturated alkyl, non-linear alkyl, branched alkyl, substituted alkyl, substituted alkyl or cyclic alkyl, or R 1 and R 2 together with the nitrogen atom to which they are attached form a heterocycle;
and a pharmaceutically acceptable excipient.
2. A pharmaceutical composition comprising 17-hydroxy wortmannin compound having the structure:
wherein:
R 1 and R 2 are independently unsaturated alkyl, non-linear alkyl, branched alkyl, substituted alkyl, substituted alkyl or cyclic alkyl, or R 1 and R 2 together with the nitrogen atom to which they are attached form a heterocycle;
and a pharmaceutically acceptable excipient.
3. A method of treating cancer comprising administering to a subject a therapeutically effective amount of the composition of claim 1 .
4. A method of treating cancer comprising administering to a subject a therapeutically effective amount of the composition of claim 2 .