Antifungal composition with enhanced bioavailability
A liquid suspension comprising an antifungally effective amount of the micronized compound represented by the chemical structural formula I: at least one thickening agent, a non-ionic surfactant, and a pharmaceutically acceptable liquid carrier is disclosed.
1. A liquid suspension comprising:
40 mg/ml of a micronized compound represented by the chemical structural formula I:
wherein the micronized compound of formula I has a mean particle size of about 1800 nm;
Polysorbate 80;
an effective amount of a buffer system comprising sodium citrate and citric acid sufficient to maintain a pH in the range of about 4.0 to about 6.0;
a combination of thickening agents comprising xanthan gum and liquid sugar; and
a pharmaceutically acceptable liquid carrier comprising glycerin.
2. A liquid suspension comprising:
40 mg/ml of a micronized compound represented by the chemical structural formula I:
wherein the micronized compound of formula I has a mean particle size of about 1000 nm to about 1800 nm;
Polysorbate 80;
an effective amount of a buffer system comprising sodium citrate and citric acid sufficient to maintain a pH in the range of about 4.0 to about 6.0;
a combination of thickening agents comprising xanthan gum and liquid sugar; and
a pharmaceutically acceptable liquid carrier comprising glycerin.
3. A liquid suspension comprising:
posaconazole (micronized), represented by the chemical structural formula I:
wherein the micronized compound of formula I has a mean particle size of about 1000 nm to about 1800 nm in an amount of about 40 mg/ml;
Polysorbate 80, in an amount between about 5 mg/ml and about 50 mg/ml;
sodium citrate, in an amount between about 0.4 and about 0.8 mg/ml;
citric acid, in an amount between about 0.36 and about 0.6 mg/ml;
simethicone, in an amount between about 2 mg/ml and about 4 mg/ml;
xanthan gum, in an amount between about 1 mg/ml and about 5 mg/ml;
sodium benzoate, in an amount between about 0.5 mg/ml and about 3 mg/ml;
liquid glucose, in an amount between about 200 mg/ml and about 500 mg/ml; and
glycerin, in an amount between about 50 mg/ml and about 150 mg/ml.
4. The liquid suspension of claim 1 , wherein the suspension further comprises purified water.
5. The liquid suspension of claim 1 , wherein the suspension further comprises:
artificial cherry flavor, in an amount between about 2 mg/ml and about 10 mg/ml; and
titanium dioxide, in an amount about 2 mg/ml and about 6 mg/ml.