Oral rehydration composition
Disclosed are oral rehydration compositions with sucrose, sodium, chloride, and citric acid or citrate. The composition further comprises an osmolarity of below 250 mOsm/L, and sodium below 75 meq/L. Further disclosed are methods of treatment using the same.
1. An oral rehydration composition, comprising:
a) at least 40% w/w sucrose;
b) between 3% w/w and 5% w/w sodium;
c) between 0.1% w/w chloride and less than 1.5% w/w chloride;
d) potassium, at a level less than 5% w/w;
e) between 20% w/w and 30% w/w citric acid or citrate; and
f) glucose, at a level less than 0.5% w/w;
wherein the composition has a w/w ratio of sodium ions to chloride ions of at least 5:1, and wherein, upon mixture with an effective amount of water, the composition has an osmolarity of between 230 mOsm/L and 240 mOsm/L.
2. The oral rehydration composition of claim 1 , comprising between 0.1% w/w and less than 0.8% w/w chloride.
3. The oral rehydration composition of claim 1 , comprising about 1400 mmol/L sucrose upon mixture with an effective amount of water.
4. The oral rehydration composition of claim 1 , comprising a w/w ratio of sodium ions to chloride ions of at least 7:1.
5. The oral rehydration composition of claim 1 , comprising glucose, in an amount less than 0.1% w/w.
6. The oral rehydration composition of claim 1 , further comprising fructose, in an amount less than 20% w/w.
7. An oral rehydration composition, comprising:
a) at least 40% w/w sucrose; and
b) glucose, at a level less than 0.5% w/w; and
c) sodium; chloride; potassium; and citric acid or citrate;
wherein the composition has a w/w ratio of sodium ions to chloride ions of at least 5:1; and
wherein upon mixture with an effective amount of water, the composition comprises:
i) between 50 meq/L sodium and 70 meq/L sodium;
ii) between 3 mmol/L chloride and less than 10 mmol/L chloride;
iii) potassium, at a concentration less than 35 mmol/L;
iv) between 170 meq/L citric acid or citrate and 130 meq/L citric acid or citrate; and
v) an osmolarity of between 230 mOsm/L and 240 mOsm/L.
8. The oral rehydration composition of claim 1 wherein the composition comprises between 0.1% w/w chloride and 0.7% w/w chloride.
9. The oral rehydration composition of claim 1 wherein the composition comprises between 0.1% w/w chloride and 0.66% w/w chloride.
10. The oral rehydration composition of claim 7 wherein upon mixture with a suitable amount of water, the composition comprises about 7.8 mmol/L chloride.
11. A method of treating dehydration in a subject in need thereof, comprising administering to the subject the composition of claim 1 or 7 .
12. The method of claim 11 , wherein the subject is an athlete or a child.
13. The method of claim 11 , wherein the subject is suffering from diarrhea.
14. The method of claim 11 , wherein the subject is suffering from cholera.