Mutations in OAS1 genes
Modified amino acid sequences of OAS1 proteins in non-human primates, and genes related thereto, are provided.
1. An oligoadenylate synthetase 1 protein consisting of a polypeptide that has the amino acid sequence of SEQ ID NO:1 except (a) the amino acid at position 1 is deleted, (b) the amino acid at position 162 is Gly, and (c) there is an amino acid substitution at position 104.
2. The protein of claim 1 wherein the amino acid at position 104 is Lys.
3. A therapeutic composition for treating infection by a virus in a mammal wherein said composition comprises a pharmaceutically acceptable carrier and an oligoadenylate synthetase 1 protein consisting of a polypeptide that has the amino acid sequence of SEQ ID NO:1 except (a) the amino acid at position 1 is deleted, (b) the amino acid at position 162 is Gly, and (c) there is an amino acid substitution at position 104.
4. An oligoadenylate synthetase 1 protein consisting of a polypeptide that has the amino acid sequence of SEQ ID NO:1 except (a) the amino acid at position 1 is deleted, (b) the amino acid at position 162 is Gly, (c) there is an amino acid substitution at position 104, and (d) there is an amino acid substitution at a position selected from the group consisting of position 31, 115, 127, 295 and 315.
5. The composition of claim 3 wherein the amino acid at position 104 is Lys.
6. The therapeutic composition of claim 3 wherein the virus is a flavivirus.
7. The therapeutic composition of claim 3 wherein the virus is hepatitis C virus.
8. A kit comprising the therapeutic composition of claim 3 .
9. The kit of claim 8 further comprising instructions in a form prescribed by a governmental agency that regulates the manufacture, use or sale of pharmaceuticals or biological products.
10. A therapeutic composition for treating infection by a virus in a mammal wherein said composition comprises a pharmaceutically acceptable carrier and an oligoadenylate synthetase 1 protein consisting of a polypeptide that has the amino acid sequence of SEQ ID NO:1 except (a) the amino acid at position 1 is deleted, (b) the amino acid at position 162 is Gly, (c) there is an amino acid substitution at position 104, and (d) there is an amino acid substitution at a position selected from the group consisting of position 31, 115, 127, 295 and 315.