Methods of treatment with drug delivery after biodegradation of the stent scaffolding
Disclosed is a stent comprising a bioabsorbable polymeric scaffolding; and a plurality of depots in at least a portion of the scaffolding, wherein the plurality of depots comprise a bioabsorbable material, wherein the degradation rate of all or substantially all of the bioabsorbable polymer of the scaffolding is faster than the degradation rate of all or substantially all of the bioabsorbable material of the depots.
1. A method of treating a body lumen of a patient, the method comprising:
deploying a first stent at a treatment area in a body lumen of a patient, wherein the first stent comprises a bioabsorbable polymeric scaffolding and a plurality of depots in at least a portion of the scaffolding, wherein the depots have a bioabsorbable material, and wherein the degradation rate of all or substantially all of the bioabsorbable polymer of the scaffolding is faster than the degradation rate of all or substantially all of the bioabsorbable material in the depots; and
after deployment of the first stent, deploying a second stent in at least a portion of the treatment area.
2. The method according to claim 1 , wherein an anti-inflammatory agent is mixed or dispersed within the scaffolding of the first stent.
3. The method according to claim 1 , wherein an anti-inflammatory agent is delivered from at least a portion of the bioabsorbable material of the depots of the first stent.
4. The method according to claim 1 , wherein an anti-inflammatory agent is delivered from the scaffolding of the first stent and suppresses inflammation of the body lumen during substantial or complete degradation of the scaffolding.
5. The method according to claim 1 , wherein the first stent comprises an anti-proliferative agent.
6. The method according to claim 1 , wherein the second stent is deployed when the scaffolding of the first stent has substantially or completely degraded.
7. The method according to claim 1 , wherein the bioabsorbable material of the depots of the first stent is capable of at least partially eluting a drug when the second stent is deployed.
8. The method according to claim 1 , wherein upon deployment of the first stent in the treatment area, the scaffolding substantially or completely degrades from the treatment area before the bioabsorbable material of the depots substantially or completely degrades.
9. The method according to claim 1 , wherein the bioabsorbable material of the depots of the first stent delivers a drug to the body lumen during degradation of the scaffolding and after substantial or complete degradation of the scaffolding of the first stent.
10. The method according to claim 1 , wherein the bioabsorbable material of the depots of the first stent becomes endothelialized in a wall of the body lumen and delivers a drug after the scaffolding of the first stent has substantially or completely degraded.
11. The method according to claim 10 , wherein the endothelialized bioabsorbable material of the depots of the first stent elutes at least part of the drug while the second stent is implanted.
12. The method according to claim 1 , wherein the second stent comprises a bioabsorbable scaffolding.
13. The method according to claim 1 , wherein the second stent comprises a biostable scaffolding.