Composition for the treatment of ear infections and method
A composition for treating ear infections in animals includes an antifungal agent, an antibiotic agent, a steroidal anti-inflammatory agent, and an acid dissolved to form a liquid. The acid aids in keeping the steroidal anti-inflammatory agent in solution, and enhances the bactericidal effect of the composition. The method of preparing such composition includes dissolving the antifungal agent, steroidal anti-inflammatory agent, and acid in dehydrated alcohol, dissolving the antibiotic agent in propylene glycol, combining the two solutions together, heating the combination and then cooling the composition. Several drops of the composition are applied at least twice per day to the affected area of the animal's ear.
1. A composition for topical treatment of ear infections in animals comprising:
a. an antifungal agent;
b. an antibiotic agent;
c. a steroidal anti-inflammatory agent; and
d. an anhydrous organic acid;
e. liquid dehydrated alcohol; and
f. propylene glycol.
2. The composition of claim 1 wherein said antifungal agent is selected from the group of antifungal agents consisting of polyenes, azoles, allylamines, morpholines, antimetabolites, and combinations thereof.
3. The composition of claim 1 wherein said antifungal agent is a topical antifungal agent.
4. The composition of claim 1 wherein said antifungal agent is selected from the group of antifungal agents consisting of amphotericin, nystatin, fluconazole, itraconazole, clotrimazole, ketoconazole, terbinafine, 5-fluorocytosine, and combinations thereof.
5. The composition of claim 1 wherein said antifungal agent is present in a concentration of approximately 5 to 50 grams per liter of said composition.
6. The composition of claim 1 wherein said antibiotic agent is selected from the group consisting of ofloxacin, ciprofloxacin, neomycin, polymixin B, enrofloxacin, marbofloxacin, orbofloxacin, and combinations thereof.
7. The composition of claim 1 wherein said antibiotic agent is present in a concentration of approximately 0.5 to 5 grams per liter of said composition.
8. The composition of claim 1 wherein said steroidal anti-inflammatory agent is selected from the group of steroidal anti-inflammatory agents consisting of triamcinolone, betamethesone, hydrocortisone, dexamethasone, and combinations thereof.
9. The composition of claim 1 wherein said steroidal anti-inflammatory agent is present in a concentration of approximately 0.25 to 2.5 grams per liter of said composition.
10. The composition of claim 1 wherein said anhydrous organic acid is selected from the group of acids consisting of citric acid, ascorbic acid, glycolic acid, tartaric acid, and combinations thereof.
11. The composition of claim 1 wherein said anhydrous organic acid is present in a concentration of at least approximately 3 grams per liter of said composition.
12. The composition of claim 1 wherein said composition is homogeneous.
13. The composition of claim 1 wherein
a. the antifungal agent includes ketoconazole;
b. the antibiotic agent includes ofloxacin;
c. the steroidal anti-inflammatory agent includes triamcinolone diacetate; and
d. the anhydrous organic acid includes citric acid.