Methods and compositions for diagnosis and treatment of cancer
View Patent ↗The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of colorectal, in particular colonic, and gastric tumor tissues and colorectal, in particular colonic, and gastric tissues, and which represent targets for therapy or diagnosis of such tumor diseases in a subject.
1. A method of detecting a tumor antigen peptide comprising the amino acid sequence of a tumor antigen encoded by a nucleic acid sequence of SEQ ID NO:1 in a patient, the method comprising
obtaining a biological sample isolated from said patient,
contacting said biological sample with an antibody which binds to amino acids 120-132 of SEQ ID NO:2 to form a detectable complex, and
detecting whether said tumor antigen peptide is present in said sample by detecting the formation of said complex.
2. The method of claim 1 , wherein the biological sample is from a tissue or organ wherein the cells when the tissue or organ is free of tumors do not detectably express said tumor antigen and/or a nucleic acid encoding said tumor antigen.
3. The method of claim 1 , wherein the antibody further comprises a detectable label.
4. The method of claim 1 , wherein the tumor antigen comprises the amino acid sequence according to SEQ ID NO: 2.
5. The method of claim 1 , wherein the antibody is a monoclonal, chimeric, human or humanized antibody, or is a fragment of an antibody or a synthetic antibody.