Multi-modality nanoparticles having optically responsive shape
In certain embodiments novel nanoparticles (nanowontons) are provided that are suitable for multimodal imaging and/or therapy. In one embodiment, the nanoparticles include a first biocompatible (e.g., gold) layer, an inner core layer (e.g., a non-biocompatible material), and a biocompatible (e.g., gold) layer. The first gold layer includes a concave surface that forms a first outer surface of the layered nanoparticle. The second gold layer includes a convex surface that forms a second outer surface of the layered nanoparticle. The first and second gold layers encapsulate the inner core material layer. Methods of fabricating such nanoparticles are also provided.
1. A layered nanoparticle characterized by having a first concave external surface and a second convex external surface, said nanoparticle comprising:
a first biocompatible layer comprising a first surface and a second surface, the first surface being substantially concave and forming said first concave external surface of the layered nanoparticle;
a second biocompatible layer comprising a first surface and a second surface, the second surface being substantially convex and forming said second convex external surface of the layered nanoparticle; wherein the first biocompatible layer ranges in thickness from about 1 nanometer to about 50 nanometers, wherein the inner core material ranges in thickness from about 1 nanometer to about 100 nanometers, and wherein the second biocompatible layer ranges in thickness from about 1 nanometer to about 50 nanometers and
an inner core material encapsulated between, the first and second biocompatible layers.
2. The layered nanoparticle of claim 1 , wherein said inner core material comprises a material selected from the group consisting of a ferro-magnetic material, a paramagnetic material, a superparamagnetic material, a radioactive material, a pharmaceutical, and a toxin.
3. The layered nanoparticle of claim 1 , wherein the inner core material comprises a non-biocompatible material.
4. The layered nanoparticle of claim 3 , wherein the said inner core material comprises a radioactive material.
5. The layered nanoparticle of claim 1 , wherein the inner core material comprises a ferro-magnetic material.
6. The layered nanoparticle of claim 5 , wherein the inner core material comprises a ferro-magnetic material comprising a material selected from a group consisting of iron (Fe), nickel (Ni), cobalt (Co), gadolinium (Gd), an alloy thereof, a nitrate thereof, a nitrite thereof, a nitride thereof, and an oxide thereof.
7. The layered nanoparticle of claim 6 , wherein the said inner core material comprises a radioactive material selected from the group consisting of 125 I, 35 S, 14 C, 32 P, 11 C, 38 K, 89 K, 89 Zr, 217 Bi, 99 Tc, 203 Pb, 67 Ga, 68 Ga, 72 As, 111 In, 113m In, 97 Ru, 62 Cu, 64 Cu, 52 Fe, 52m Mn, 51 Cr, 186 , Re, 188 Re, 77 As, 90 Y, 67 Cu, 169 Er, 121 Sn, 127 Te, 142 Pr, 143 Pr, 198 Au, 199 Au, 161 Tb, 109 Pd, 165 Dy, 149 Pm, 151 Pm, 153 Sm, 157 Gd, 159 Gd, 166 Ho, 172 Tm, 169 Yb, 175 Yb, 177 Lu, 105 Rh, 90 Y, 131 I, 123 I, 99 In, 131 I, 64 Cu, 68 Ga, and 111 Ag.
8. The layered nanoparticle of claim 1 , wherein the first biocompatible layer comprises a material selected from the a group consisting of gold, aluminum, titanium, niobium, tantalum, nickel, ruthenium, rhodium, palladium, silver, osmium, iridium, platinum, nitenol, a cobalt base alloy, an alloy thereof, a nitrate thereof, a nitrite thereof, a nitride thereof, and an oxide thereof.
9. The layered nanoparticle of claim 8 , wherein the first biocompatible layer and the second biocompatible layer comprise the same material.
10. The layered nanoparticle of claim 1 , wherein the first biocompatible layer and the second biocompatible layer comprise different materials.
11. The layered nanoparticle of claim 1 , wherein the layered nanoparticle is configured to absorb radiation over a range selected from a group consisting of infrared wavelength, visible light wavelength, ultraviolet wavelength, microwave wavelength, and x-ray wavelength.
12. The layered nanoparticle of claim 1 , wherein the first biocompatible layer comprises gold, wherein the inner core material comprises cobalt, and wherein the second biocompatible layer comprises gold.
13. The layered nanoparticle of claim 1 , wherein a longest dimension of the layered nanoparticle is less than or equal to about 500 nanometers.
14. The layered nanoparticle of claim 1 , wherein the layered nanoparticle is attached to a moiety selected from a group consisting of a protein, an antibody, a lectin, and a nucleic acid.
15. The layered nanoparticle of claim 1 , wherein said the second biocompatible layer comprises a material selected from the a group consisting of gold, aluminum, titanium, niobium, tantalum, nickel, ruthenium, rhodium, palladium, silver, osmium, iridium, platinum, nitenol, and a cobalt base alloy, an alloy thereof, a nitrate thereof, a nitrite thereof, a nitride thereof, and an oxide thereof.
16. The layered nanoparticle of claim 15 , wherein the first biocompatible layer and the second biocompatible layer comprise the same material.
17. The layered nanoparticle of claim 1 , wherein said nanoparticle is configured to absorb radiation at a near-infrared wavelength.
18. The layered nanoparticle of claim 1 , wherein said nanoparticle is configured to absorb radiation at a wavelength of about 700 nm.