Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer

1. A liquid composition comprising

a compound having structural formula (II), or a salt or solvate thereof; and

a phenol-based antioxidant, or a salt or solvate thereof, as a photostabilizer for the compound having structural formula (II);

wherein:

the phenol-based antioxidant is selected from the group consisting of a dihydrochalcone derivative, a flavanone derivative, a coumarine derivative, a phenylpropenoic carbonyl compound, and a combination thereof;

the compound having structural formula (II):

wherein,

A is —OR 9 , —NO 2 , —NHOR 9 , —NR 9 COR 10 , —NR 9 R 10 , or —NR 9 CO 2 R 10 ;

R 17 is hydrogen, alkyl, or substituted alkyl;

X 1 is —O—, —NR 9 —, or —S—;

X 2 is alkylene, substituted alkylene, heteroalkylene, or substituted heteroalkylene;

m is 1;

Y 1 is

X 3 and X 5 are independently a covalent bond, —O— or —NR 9 —;

X 4 is O;

R x is halo, —NO 2 , —CN, —OH, —NH 2 , alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl;

n is 0, 1, 2, or 3;

R y is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl, —NR 9 R 10 ; and

each R 9 and R 10 is independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroalkyl, substituted heteroalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl or substituted heteroarylalkyl.

2. The composition of claim 1 , wherein structural formula (II):

X 2 is alkanylene, substituted alkanylene, heteroalkanylene, substituted heteroalkanylene, alkenylene, substituted alkenylene, heteroalkenylene, or substituted heteroalkenylene.

3. The composition of claim 2 , wherein structural formula (II):

X 2 is methylene, ethylene, propylene, iso-propylene, butylene, iso-butylene, sec-butylene, pentylene, hexylene, heptylene, dimethylethylene, methylcyclopropylene, cyclopropylmethylene, ethenylene, propenylene, or butenylene.

4. The composition of claim 1 , wherein structural formula (II):

A is —OR 9 , —NHOR 9 , or —NR 9 R 10 .

5. The composition of claim 1 , wherein structural formula (II):

R 17 is hydrogen.

6. The composition of claim 1 , wherein structural formula (II):

—X 3 —C(X 4 )—X 5 — is —C(O)—, —C(O)—NH—, —NH—C(O)—, —NH—C(O)—NH—, —C(O)—O—, —O—C(O)—, —O—C(O)—O—, —NH—C(O)—O—, —O—C(O)—NH—.

7. The composition of claim 1 , wherein structural formula (II):

A is —NR 9 R 10 ;

R 17 is hydrogen;

and

—X 3 —C(X 4 )—X 5 — is —C(O)—, —C(O)—NH—, —NH—C(O)—, —NH—C(O)—NH—, —C(O)—O—, —O—C(O)—, —O—C(O)—O—, —NH—C(O)—O—, —O—C(O)—NH—.

8. The composition of claim 1 , wherein the sweet enhancer having structural formula (II) is selected from the group consisting of

9. The composition of claim 1 , which is in form of a solution, suspension, oil, gel, paste, porridge, or mixture thereof.

10. The composition of claim 1 , which is a food or beverage product, a pharmaceutical composition, a nutritional product, a dietary supplement, over-the-counter medication, or oral care product.

11. The composition of claim 1 , further comprising an ingestibly acceptable excipient.

12. The composition of claim 1 , further comprising a sweetener.

13. The composition of claim 12 , wherein the sweetener is selected from the group consisting of sucrose, fructose, glucose, galactose, mannose, lactose, tagatose, maltose, corn syrup (including high fructose corn syrup), D-tryptophan, glycine, erythritol, isomalt, lactitol, mannitol, sorbitol, xylitol, maltodextrin, maltitol, hydrogenated glucose syrup (HGS), hydrogenated starch hydrolysate (HSH), stevioside, rebaudioside A, other sweet Stevia -based glycosides, carrelame, other guanidine-based sweeteners, saccharin, acesulfame-K, cyclamate, sucralose, alitame, mogroside, neotame, aspartame, other aspartame derivatives, and combinations thereof.

14. The composition of claim 1 , wherein the phenol-based antioxidant is a naturally occurring compound or a FEMA GRAS compound.

15. The composition of claim 1 , wherein the phenol-based antioxidant is selected from the group consisting of caffeic acid, ferulic acid, sinapinic acid, rosmarinic acid, chlorogenic acid (CGA), cichoric acid, caftaric acid, echinacoside, myricitrin, myricetin, apigenin, kaempferol, rhoifolin, luteolin, diosmin, apiin, morin, neodiosmin, quercetin, rutin, cupressuflavone, datiscetin, diosmetin, fisetin, galangin, gossypetin, geraldol, hinokiflavone, scutellarein, primuletin, pratol, robinetin, quercetagetin, chrysoeriol, isorhamnetin, vitexin, isoquercitrin, daidzin, daidzein, biochanin A, prunetin, genistin, glycitein, glycitin, genistein, 6,7,4′-trihydroxyisoflavone, 7,3′,4′-trihydroxyisoflavone, coumarin, dalbergin, daphnetin, esculetin, umbelliferone, scopoletin, xanthotoxol, fraxetin, butein, phloridzin, echinatin, marein, isoliquiritigenin, phloretin, polyhydroxychalcones, phloretin, trilobtain, naringin dihydrochalcone, neohesperidin dihydrochalcone, naringenin, homoeriodictyol, hesperetin, enzymatically modified isoquercitrin (EMIQ), and a combination thereof.

16. The composition of claim 15 , wherein the phenol-based antioxidant is selected from the group consisting of EMIQ, chlorogenic acid, rutin, myricitrin, naringin dihydrochalcone, neohesperidin dihydrochalcone, naringenin, phloretin, trilobtain, caffeic acid, ferulic acid, sinapinic acid, scopoletin, daphnetin, and a combination thereof.