Tetrahydronaphthalene derivatives
This invention relates to novel tetrahydronaphthalene derivatives, and pharmaceutically acceptable salts thereof according to the following formulae, in one embodiment: as described herein. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a selective T-type calcium channel blocker.
1. A compound of Formula C:
which is Compound 703a, or a pharmaceutically acceptable salt thereof, wherein in Compound 703a:
R 1 is CD 3 ; Y 8 and Y 9 are each hydrogen; R a and R b are each —CH 3 ; each of Y 3a , Y 3b , Y 5a , and Y 5b is hydrogen; each of Y 2a , Y 2b , Y 6a , Y 6b , Y 7a and Y 7b is D;
is CH 2 OCH 3 , and
wherein any atom not designated as deuterium is present at its natural isotopic abundance.
2. A pyrogen free pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
3. A method of treating a disease or condition selected from angina pectoris, ischemia, arrhythmias, congestive heart failure, high blood pressure, cardiac insufficiency, pain, visceral pain and diabetic complications in a subject comprising the step of administering to the subject in need thereof a composition of claim 2 .