Granted Patent
B2
US 8,388,960 · App. 13/229,422 · Granted Mar 5, 2013
Elimination of heterogeneous or mixed cell population in tumors
Inventors:
Viktor S. Goldmakher (Newton, MA); Robert J. Lutz (Wayland, MA); Ravi V. J. Chari (Newton, MA); Yelena V. Kovtun (Stow, MA); John M. Lambert (Cambridge, MA); Rita Steeves (Stoneham, MA); Hans K. Erickson (Belmont, MA); Wayne C. Widdison (Belmont, MA)
Assignee:
Immunogen Inc.
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Abstract
Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cell populations is described. The killing or inhibition of tumors is achieved by selectively targeting a unique ligand suspected of being expressed on a particular cell population to also kill a cell population lacking the unique ligand. These conjugates have therapeutic use as they are delivered to a specific cell population to kill these cells and the cytotoxic drug is released to kill non-targeted cells, thereby eliminating the tumor.
Claims (5)
1. An isolated alkylated maytansinoid, which has the following formula:
MayO(C═O)CH(Me)N(CH 3 )COCH 2 CH 2 (CMe 2 ) n SMe
wherein, n=0, and May=maytansinoid.
2. Isolated S-methyl-DM1.
3. Isolated lysine-N ε -SMCC-DM1.
Assignments (2)
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE PREVIOUSLY RECORDED ON REEL 029434 FRAME 0308. ASSIGNOR(S) HEREBY CONFIRMS THE RE-RECORD ASSIGNMENT UNDER REEL/FRAME 029434/0308 TO CORRECT ASSIGNEE ADDRESS FROM WALTHAM, ME 02451 TO WALTHAM, MA 02451.
Recorded Dec 18, 2012
From: WIDDISON, WAYNE C
To: IMMUNOGEN, INC.
Reel/Frame 029489/0305 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 10, 2012
From: WIDDISON, WAYNE C
To: IMMUNOGEN, INC.
Reel/Frame 029434/0308 →
Continuity (5)
Provisional Application
60671498
· Apr 15, 2005
Provisional Application
60781722
· Mar 14, 2006