IP Library › Granted Patent US 12,186,411
Granted Patent B2
US 12,186,411 · App. 17/521,974 · Granted Jan 7, 2025

Labeled probe and methods of use

Inventors: Michelle L. James (Menlo Park, CA); Katrin I. Andreasson (Stanford, CA)
Assignee: The Board of Trustees of Leland Stanford Junior University
A61K51/1027A61K51/1093C07K16/2803
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Quick Facts
Patent No.
US 12,186,411
App. No.
17/521,974
Granted
Jan 7, 2025
Kind
B2
Abstract

The present disclosure provides for methods and compositions useful for imaging inflammation and inflammatory disease markers with an affinity for TREM-1 antibodies. The methods and compositions can include a labeled probe having a TREM-1 antibody and a radiolabel.

Claims (15)

1. A method of monitoring the progress of neurological tissue inflammation from a neurological disease in a subject, the method comprising:

administering to a subject a labeled probe, wherein the labeled probe includes a TREM-1 antibody and a radiolabel, and wherein the radiolabel is selected from 64 Cu, 18 F, and 89 Zr;

imaging at least a portion of the subject; and

detecting a signal from the labeled probe, wherein detecting the signal corresponds to detecting the neurological tissue inflammation, wherein the signal is monitored over time.

2. The method of claim 1 , wherein the neurological disease is selected from the group consisting of Alzheimer's disease, multiple sclerosis, epilepsy, traumatic brain injury, Huntington's disease, amyotrophic lateral sclerosis, Parkinson's disease, sepsis, stroke, chronic fatigue syndrome, depression, and schizophrenia.

3. The method of claim 1 , wherein the detection of the labeled probe is performed in vitro using Positron Emission Tomography (PET), Computerized Tomography (CT), or a combination thereof.

4. The method of claim 1 , wherein chelator is (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid).

5. The method of claim 1 , wherein chelator is NOTA (1,4,7-Triazacyclononane-1,4,7-triacetic acid).

6. The method of claim 1 , wherein chelator is EDTA (Ethylenediaminetetraacetic acid).

7. The method of claim 1 , wherein chelator is Df (Desferrioxamine).

8. The method of claim 1 , wherein chelator is DTPA (Diethylenetriaminepentaacetic acid).

9. The method of claim 1 , wherein chelator is and TETA (Triethylenetetramine).

10. The method of claim 1 , wherein the radiolabel is 64 Cu.

11. The method of claim 1 , wherein the radiolabel is 18 F.

12. The method of claim 1 , wherein the radiolabel is 89 Zr.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 28, 2022
From: JAMES, MICHELLE L.; ANDREASSON, KATRIN I.
To: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Reel/Frame 058802/0236 →
Continuity (3)
Division 15775450
Provisional Application 62254396 · Nov 12, 2015
Related Publication 20220062449A1 · Mar 3, 2022
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