Wound care device
A wound care device for local treatment of pain in a wound, said device comprising an active pain relieving composition, the device being constructed in such a manner that the pain killing agent is released to the wound in such a way that substantially no effective systemic plasma concentration of the pain killing agent can be found and wherein a majority of said pain killing agent is in direct contact with the wound.
1. A wound care device for local treatment of pain in a wound, said device comprising (1) a substantially water-impervious layer or film, (2) a skin-friendly adhesive in which an absorbing constituent or element is incorporated, and (3) a relatively thin wound contacting layer which incorporates a pain killing agent in an amount less than 75% of the systemic daily unit dose for systemic treatment using the agent.
2. The wound care device according to claim 1 , wherein the pain-killing agent is an anti-inflammatory pain-killing agent.
3. The wound care device according to claim 1 wherein the pain-killing agent is an NSAID.
4. The wound care device according to claim 3 , wherein the pain-killing agent is ibuprofen.
5. The wound care device according to claim 1 , wherein the pain-killing agent is incorporated into the wound contacting layer as particles.
6. The wound care device according to claim 5 , wherein the particles are incorporated in a film.
7. The wound care device according to claim 1 , wherein one or more components are made of a material selected from the group of PVP, PVA, polylactic acids, polysaccharides such as carboxy methyl cellulose (CMC), hydroxymethyl cellulose, chitosan, alginate, or polyacrylic acids, methacrylates, silicones, styrene-isoprene-styrene mixtures, Vaseline, glycols and polyurethane.
8. The wound care device according to claim 1 , wherein at least 50% w/w of the pain-killing agent is released during the first 24 hours after application of the wound care device to a wound.
9. The wound care device according to claim 1 , wherein at least 50% w/w of the pain-killing agent is released during the first 12 hours after application of the wound care device to a wound.
10. The wound care device according to claim 1 , wherein at least 75% w/w of the pain-killing agent is released during the first 24 hours after application of the wound care device to a wound.
11. The wound care device according to claim 1 , wherein at least 75% w/w of the pain-killing agent is released during the first 12 hours after application of the wound care device to a wound.
12. The wound care device according to claim 1 , wherein at least 75% w/w of the pain-killing agent is released during the first 6 hours after application of the wound care device to a wound.
13. The wound care device according to claim 1 , wherein the wound care device has a thickness of less than 1.5 mm.
14. The wound care device according to claim 1 , wherein the wound care device has a thickness of less than 1.0 mm.
15. The wound care device according to claim 1 , wherein the wound care device has a thickness of less than 0.7 mm.
16. The wound care device according to claim 1 , wherein the wound care device has a thickness of less than 0.6 mm.
17. The wound care device according to claim 1 , wherein the wound care device has a thickness of less than 0.5 mm.
18. A wound care device for local treatment of pain in a wound, said device comprising (1) a substantially water-impervious layer or film, (2) a skin-friendly adhesive in which an absorbing constituent or element is incorporated, and (3) a relatively thin wound contacting layer incorporating a pain killing agent which is released to the wound so that the plasma concentration of the pain killing agent is below that needed for systemic effect.
19. The wound care device according to claim 7 , wherein one or more components are made of a glycol selected from the group consisting of PEG or PEG/PPG mixtures.