Organic compounds
The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
1. 2-(3-Benzyl-2-oxoimidazolidin-1-yl)-4-methyl-N-(pyridin-2-ylmethyl)thiazole-5-carboxamide, or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition, comprising:
a therapeutically effective amount of 2-(3-benzyl-2-oxoimidazolidin-1-yl)-4-methyl-N-(pyridin-2-ylmethyl)thiazole-5-carboxamide, or a pharmaceutically acceptable salt thereof, in combination with a therapeutically effective amount of insulin, an insulin derivative or mimetic, an insulin secretagogue, an insulinotropic sulfonylurea receptor ligand, a PPAR ligand, an insulin sensitizer, a biguanide, an alpha-glucosidase inhibitor, GLP-1, a GLP-1 analog or mimetic, a DPPIV inhibitor, a HMG-CoA reductase inhibitor, a squalene synthase inhibitor, a FXR or LXR ligand, cholestyramine, a fibrate, nicotinic acid, or aspirin.