IP Library › Patent Application 13231537
Patent Application
App. No. 13/231,537

METHODS FOR GENERATING ANTI-IL-23 ANTIBODIES, COMPOSITIONS, METHODS AND USES

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Patent No.
US None
App. No.
13/231,537
Abstract

A protein variant of IL-23p19 that has conserved residues in positions 93-102, 93-110, and/or 127-137 of SEQ ID NO:1, can be used to generate anti-IL-23p19 antibodies.

Claims (15)

1 . A method for generating an antibody, comprising panning an antibody library with an isolated IL-23p19 variant protein, comprising an amino acid sequence having less than 50% identity to the amino acid sequence of SEQ ID NO:1 wherein said protein has the identical amino acid sequence at residues 93-102, 93-110, and/or 127-137 of SEQ ID NO:1, and isolating an antibody or antibody fragment binding to the IL-23p19 variant protein.

2 . The method of claim 1 , wherein said protein has less than 60% identity to the amino acid sequence of SEQ ID NO:1.

3 . The method of claim 1 , wherein said protein has less than 70% identity to the amino acid sequence of SEQ ID NO:1.

4 . The method of claim 1 , wherein said protein has less than 80% identity to the amino acid sequence of SEQ ID NO:1.

5 . The method of claim 1 , wherein said protein has less than 90% identity to the amino acid sequence of SEQ ID NO:1.

6 . The method of claim 1 , wherein said protein has less than 95% identity to the amino acid sequence of SEQ ID NO:1.

7 . A method for generating an antibody, comprising contacting an animal producing antibodies with an isolated IL-23p19 variant protein, comprising an amino acid sequence having less than 50% identity to the amino acid sequence of SEQ ID NO:1 wherein said protein has the identical amino acid sequence at residues 93-102, 93-110, and/or 127-137 of SEQ ID NO:1, and isolating an antibody or antibody fragment binding to the IL-23p19 variant protein.

8 . The method of claim 7 , wherein said protein has less than 60% identity to the amino acid sequence of SEQ ID NO:1.

9 . The method of claim 7 , wherein said protein has less than 70% identity to the amino acid sequence of SEQ ID NO:1.

10 . The method of claim 7 , wherein said protein has less than 80% identity to the amino acid sequence of SEQ ID NO:1.

11 . The method of claim 7 , wherein said protein has less than 90% identity to the amino acid sequence of SEQ ID NO:1.

12 . The method of claim 7 , wherein said protein has less than 95% identity to the amino acid sequence of SEQ ID NO:1.

13 . The method of claim 7 , wherein the animal producing antibodies is selected from the group consisting of mice, rats, rabbits, camel, goats, cows, horses, sheep, and non-human primates.

14 . The method of claim 13 , wherein the animal producing antibodies is a transgenic animal capable of producing antibodies with human sequences.

15 . Any invention described herein.