IP Library › Patent Application 13244981
Patent Application
App. No. 13/244,981

EXPANSION OF NK CELLS AND THERAPEUTIC USES THEREOF

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Quick Facts
Patent No.
US None
App. No.
13/244,981
Abstract

The present invention relates to novel methods for preferentially activating and expanding NK cells. The methods utilize the stimulatory effects of IL-15 and CD137 ligand to preferentially expand and activate NK cells in a mixed cell culture comprising NK cells.

Claims (1)

1 . A modified cell line comprising cells that lack major histocompatability complex I molecules wherein said cells are genetically modified to express membrane bound interleukin-15 and a co-stimulatory factor ligand CD137L, where said modified cell line activates natural killer (NK) cells and fail to activate T lymphocytes.