IP Library › Granted Patent US 8,470,785
Granted Patent B2
US 8,470,785 · App. 13/246,202 · Granted Jun 25, 2013

Method for treating ocular cancer

Inventors: Michael A. Dyer (Memphis, TN); Jean-Christophe Marine (Erbisoeul, BE); Aart Gerrit Jochemsen (Leiden, NL); R. Kip Guy (Memphis, TN); Fangyi Zhu (Memphis, TN)
Assignees: St. Jude Children's Research Hospital; Leiden University Medical Center; VIB VZW and Universiteit Gent
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Quick Facts
Patent No.
US 8,470,785
App. No.
13/246,202
Granted
Jun 25, 2013
Kind
B2
Abstract

Compositions and methods for treating ocular cancer are provided. The composition is a subconjunctival formulation of nutlin-3 and its analogs. The composition provides for methods of treating ocular cancer, including retinoblastoma. The formulation has high penetration into ocular tissue with low toxicity.

Claims (4)

1. A composition for treating ocular cancer comprising an effective amount of nutlin-3 or a nutlin-3 analog in a solution consisting of polypropylene glycol (pPPG), propropolene glycol (PPG), polyoxyl 35 castor oil (Cremophor eL), and phosphate-buffered saline (PBS), wherein said nutlin-3 analog is nutlin-3a.

2. The composition of claim 1 , wherein the solution consists of 15% pPPG, up to 10% PPG, 5% Cremophor eL, and 70% PBS.

3. The composition of claim 1 , wherein the composition is co-administered with an antineoplastic agent.

4. The composition of claim 3 , wherein the antineoplastic agent is topotecan.

Assignments (4)
CONFIRMATORY LICENSE Recorded Mar 14, 2020
From: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 052166/0424 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 18, 2012
From: MARINE, JEAN-CHRISTOPHE
To: VIB VZW; UNIVERSITEIT GENT
Reel/Frame 027551/0673 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 28, 2011
From: DYER, MICHAEL A.; GUY, R. KIP
To: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Reel/Frame 027139/0705 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 28, 2011
From: JOCHEMSEN, AART GERRIT
To: LEIDEN UNIVERSITY MEDICAL CENTER
Reel/Frame 027139/0846 →
Continuity (3)
Continuation In Part 12373308
Provisional Application 60820652 · Jul 28, 2006
Related Publication 20120115880A1 · May 10, 2012