Sirtuin modulating compounds
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
1. A compound of the formula:
or a salt thereof.
2. A pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound of claim 1 or a salt thereof.
3. A packaged pharmaceutical comprising a compound of claim 1 or a salt thereof.
4. A method for ameliorating at least one symptom of insulin resistance, metabolic syndrome, diabetes, or for increasing insulin sensitivity in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of claim 1 or a salt thereof.
5. A method for reducing the weight of a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of claim 1 or a salt thereof.
6. A method for enhancing motor performance or muscle endurance, decreasing fatigue, or increasing recovery from fatigue, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of claim 1 or a salt thereof.
7. A method for ameliorating at least one symptom of a condition wherein motor performance or muscle endurance is reduced, wherein the condition is one or more of age-related muscle wasting, and muscle atrophy and/or cachexia associated with burns, bed rest, limb immobilization, or major thoracic, abdominal, and/or orthopedic surgery, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of claim 1 or a salt thereof.
8. A method for ameliorating at least one symptom of muscle tissue damage associated with hypoxia or ischemia, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of claim 1 or a salt thereof.
9. A method for increasing muscle ATP levels in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of claim 1 or a salt thereof.