Transdermal compositions
The present invention is directed to transdermal compositions and the uses thereof. These compositions include at least one of the following components: a C 1 -C 6 dialkyl, C 12 -C 30 dialkyl quaternary ammonium salt, a C 12 -C 30 fatty acid, a nitrogenous organic base, C 12-30 fatty alcohol, monoglyceride or the reaction products thereof.
1. A composition comprising
between about 0.2 weight percent and about 5 weight percent of a tertiary amide, or a pharmaceutically acceptable salt thereof, having the structure:
wherein R 4 is a fatty group of between 11-29 carbon atoms;
wherein R 5 is a lower alkyl, aryl, aryl lower alkyl, or fatty group containing 11-29 carbon atoms or R 7
R 6 is independently R 7
R 7 is R 1 —Ar—O—R 2 —O—R 3 —;
R 2 and R 3 are independently alkylene groups containing 1-6 carbon atoms,
R 1 is an alkyl group containing 1-15 carbon atoms and
Ar is aryl,
the fatty group being completely saturated;
between about 5 and about 10 weight percent povidone iodine;
between about 1-10 weight percent of a surfactant; and
balance water.
2. The composition of claim 1 , wherein the concentration of the tertiary amide is between about 0.2 weight percent and about 2 weight percent.
3. The composition of claim 1 , wherein the concentration of povidone iodine is between about 6 weight percent and about 9 weight percent.
4. The composition of claim 1 , wherein the surfactant is a non-ionic surfactant.
5. The composition of claim 1 , wherein the surfactant is Triton X-100 and/or Nonoxynol-9.
6. The composition of claim 1 , wherein the concentration of the surfactant is between about 2 weight percent and about 8 weight percent.
7. The composition of claim 1 , wherein the concentration of the surfactant is between about 4 weight percent and about 6 weight percent.
8. The composition of claim 1 , further comprising between about 0.1 weight percent about 2 weight percent of a wax.
9. The composition of claim 1 , further comprising a quaternary ammonium salt.
10. The composition of claim 9 , wherein the concentration of the quaternary ammonium salt is between about 1 and about 4 weight percent.
11. The composition of claim 1 , further comprising a nitrogen containing base.
12. The composition of claim 11 , wherein the concentration of the nitrogen containing base is between about 0.1 weight percent to about 1 weight percent.
13. The composition of claim 11 , wherein the nitrogen containing base is selected from the group consisting of triethanolamine, trimethanolamine, trimethethylamine, triethylamine, tromethamine, trisaminoalcohol, tris(hydroxymethyl)aminomethane, tris(hydroxyethyl methyl)aminoethane and combinations thereof.
14. The composition of claim 13 , wherein the nitrogen containing base is triethanolamine.
15. The composition of claim 1 , further comprising a cationic polymer.
16. A method of treating bed sores comprising the application of a composition of claim 1 to the bed sores.
17. A method of treating subcutaneous bruising comprising the application of a composition of claim 1 to the skin adjacent to the subcutaneous brusing.
18. A method of treating skin injuries or skin irritation comprising the application of a composition of claim 1 to the injured or irritated skin.
19. A method of killing microorganisms comprising the application of a composition of claim 1 to the skin.