Intramolecular hydrogen-bonded nitric oxide synthase inhibitors
Compounds and related compositions and methods as can be used to selectively inhibit neuronal nitric oxide synthase and as can be employed in the treatment of various neurodegenerative diseases.
1. A compound selected from compounds of a formula
wherein X is selected from fluoro, hydroxy and methoxy groups, said compound in a conformation for intramolecular hydrogen-bonding; and salts thereof.
2. The compound of claim 1 wherein X is selected from fluoro and methoxy groups.
3. The compound of claim 1 wherein said compound is an ammonium salt, and said salt has a counter ion that is a conjugate base of a protic acid.
4. A compound selected from compounds of a formula
wherein X is selected from hydroxy and methoxy groups; and salts thereof.
5. The compound of claim 4 wherein X is a methoxy group.
6. The compound of claim 4 wherein said compound is an ammonium salt, and said salt has a counter ion that is a conjugate base of a protic acid.
7. A compound selected from compounds of a formula
wherein X is selected from fluoro, hydroxyl and methoxy groups; and salts thereof.
8. The compound of claim 7 wherein X is selected from fluoro and methoxy groups.
9. The compound of claim 7 wherein said compound is an ammonium salt, and said salt has a counter ion that is a conjugate base of a protic acid.
10. The compound of claim 7 comprising a cis diastereomeric configuration.